王道金,阚博,王妹,章佳慧,王定祥.重视双相障碍混合状态的临床复杂性[J].四川精神卫生杂志,2020,33(6):481-485.Wang Daojin,Kan Bo,Wang Mei,Zhang Jiahui,Wang Dingxiang,Focus on the complexity of bipolar mixed states in clinical practice[J].SICHUAN MENTAL HEALTH,2020,33(6):481-485
重视双相障碍混合状态的临床复杂性
Focus on the complexity of bipolar mixed states in clinical practice
投稿时间:2020-09-30  
DOI:10.11886/scjsws20200930001
中文关键词:  双相情感障碍  混合状态  混合发作/特征  阈下症状  DSM-5  ICD-10  非典型抗精神病药
英文关键词:Bipolar disorder  Mixed states  Mixed episode/features  Subsyndromal symptoms  DSM-5  ICD-10  Atypical antipsychotics
基金项目:
作者单位邮编
王道金 芜湖市第四人民医院芜湖 241002
蚌埠医学院精神卫生临床学院芜湖 241002 
241002
阚博 芜湖市第四人民医院芜湖 241002 241002
王妹 芜湖市第四人民医院芜湖 241002 241002
章佳慧 合肥市安康医院合肥 231100 231100
王定祥 芜湖市第四人民医院芜湖 241002 241002
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中文摘要:
      本文目的是对双相障碍混合状态的概念演变、流行病学、临床特征与当前生物学治疗证据等进行述评,以强调双相混合状态的临床复杂性及目前基于《国际疾病分类(第10版)》(ICD-10)临床诊疗的特点。根据狭义的ICD-10“混合发作”定义,临床常见的伴“相反”相阈下症状的混合状态常被忽略。未来需重视基于《精神障碍诊断与统计手册(第5版)》(DSM-5)等广义的混合状态定义进一步临床研究,以进行科学的治疗,改善患者预后。
英文摘要:
      The purpose of this paper is to review the evolution of the concept,prevalence, clinical correlates, and current evidence for biological treatments of bipolar mixed states, emphasize the illness complexities of bipolar mixed states while highlighting the gaps in clinical treatment and research using International Classification of Diseases,tenth edition (ICD-10) criteria. Narrowly defined ICD-10 mixed episodes ignores subthreshold symptoms of the opposite pole common with patients. Further clinical studies specifically designed to enroll the full range of mixed states are needed to promote appropriate treatment options and improve clinical outcomes.
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