| 于相芬,麻爱华,董俊玲.精神分裂症患者乙型肝炎病毒感染与代谢综合征的关系[J].四川精神卫生杂志,2014,27(1):33-37.YU Xiang -fen,MA Ai - hua,DONG Jun - ling,Relationship between metabolic syndrome and hepatitis B virus infection in patients with schizophrenia[J].SICHUAN MENTAL HEALTH,2014,27(1):33-37 |
| 精神分裂症患者乙型肝炎病毒感染与代谢综合征的关系 |
| Relationship between metabolic syndrome and hepatitis B virus infection in patients with schizophrenia |
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| DOI： |
| 中文关键词: 精神分裂症 乙型肝炎病毒 代谢综合征 |
| 英文关键词:Schizophrenia Hepatitis B virus Metabolic syndrome |
| 基金项目:临沂市科技发展计划项目（201313061） |
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| 中文摘要: |
| 目的 探讨精神分裂症患者乙型肝炎病毒（HBV）感染与代谢综合征（MS）的关系.方法 收集600例住院精神分裂症患者人口学资料和病史资料,测量身高、体质量、腰围、血压等生理指标,采集血清样本检测其HBV携带情况以及空腹血糖、总蛋白、白蛋白、球蛋白、肌酐、尿素氮、尿酸、甘油三酯、总胆固醇、高密度脂蛋白（HDL-C）和低密度脂蛋白（LDL-C）等生化指标,按2007年颁布的《中国成人血脂异常防治指南》中MS诊断标准诊断.结果 600例精神分裂症患者乙型肝炎表面抗原（HBsAg）阳性有71例,阳性率为11.83％.MS组HBsAg阳性率为19.78％,非MS组10.41％,差异有统计学意义（P＜0.05）.HBV感染和MS相关的粗OR为2.121,95％CI为（1.342～3.324）,调整年龄和性别后,其调整OR为2.068,95％CI为（1.322 ～3.228）.结论 HBV感染可能会增加精神分裂症患者MS的患病风险. |
| 英文摘要: |
| Objective To explore the relationship between metabolic syndrome （MS） and hepatitis B virus （HBV） infection in patients with schizophrenia. Methods 600 inpatients with schizophrenia were recruited in this study. Basic information such as the de- mographic information , medical data of the patients were recorded, physical parameters such as height, body weight, waist circumfer- ence, blood pressure were collected. Blood samples were also collected to detect the status of HBV infection and biochemical parame- ters, such as fasting blood sugar, serum total protein, albumin, globulin, creatinine, uric acid, triglyeeride, total cholesterol, high - density lipoprotein （ HDL - C ）, low - density lipoprotein （ LDL - C ）. The MS was diagnosed according to criteria defined by Preventive Guideline of Dyslipidemia for Chinese Adults. Results The prevalence of HBsAg infection was 11.83% in inpatients with schizophre- nia. Frequency of positive HBsAg infection in MS group was 19.78 % , and was higher than the frequency （ 1 0.41% ） in non - MS group （P = 0. 018）. The crude OR between MS and HBV infection was 2. 121,95% confidence interval（CI） was 1. 342 to 3. 324. Adjusted OR was 2. 068,95% CI was 1. 322 to 3. 228 after age and gender were adjusted. Conclusion HBV infection might increase the prev- alence of MS in patients with schizophrenia. |
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