| 文璐,李冰凌,马永春.抗抑郁药物治疗抑郁发作3个月引发转躁的前瞻性观察[J].四川精神卫生杂志,2015,28(1):1-3.WEN Lu,LI Bing-ling,MA Yong-chun,Prospective observation of switching rate of antidepressants in management of depressive episode in 3 months[J].SICHUAN MENTAL HEALTH,2015,28(1):1-3 |
| 抗抑郁药物治疗抑郁发作3个月引发转躁的前瞻性观察 |
| Prospective observation of switching rate of antidepressants in management of depressive episode in 3 months |
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| DOI：10.11886/j.issn.1007-3256.2015.01.001 |
| 中文关键词: 抗抑郁药物 转相 心境稳定剂 家族史 |
| 英文关键词:Antidepressants Switching Mood Stabilizer Family History |
| 基金项目:国家中医药管理局中医心理学重点学科项目(国中医药人教发2012-32);浙江省中西医结合中医临床心理学项目(2012-XK-A02);浙江省卫生厅医药科研基金资助项目(2006A017);浙江省中西结合抑郁症重点专科项目(2007) |
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| 中文摘要: |
| 目的：前瞻性探讨抗抑郁药物在治疗抑郁发作过程中出现转相的几率。方法对符合《精神障碍诊断与统计手册（第4版）》（ DSM-IV）和《中国精神障碍分类与诊断标准（第3版）》（ CCMD-3）中抑郁发作或双相抑郁诊断标准的190例接受抗抑郁药物治疗的抑郁发作患者，在医生针对性选择抗抑郁药物治疗情况下进行为期3个月的前瞻性观察，评价转相发生率。结果①3个月的治疗中，190例患者转相18例，转相率为9.47%。②男性患者转相率为6.56%，女性患者转相率为10.85%，差异无统计学意义（χ2=0.89，P>0.05）。③单相抑郁与双相抑郁患者转相率分别为5.88%和40.00%，差异有统计学意义（χ2=24.29，P<0.01）。④应用心境稳定剂与未使用心境稳定剂者转相率分别为13.8%和8.44%，差异无统计学意义（χ2=1.47，P>0.05）。⑤服用2种或2种以上抗抑郁药物者与仅服用一种抗抑郁药物者转相率分别为12.96%和8.08%，差异无统计学意义（χ2=1.07，P>0.05）。⑥有心境障碍家族史者与无心境障碍家族史者转相率分别为18.4%和7.23%，差异有统计学意义（χ2=4.43，P<0.05）。⑦转相时间大约在用药后一个月左右。⑧各种抗抑郁药物转相几率差异不明显。结论抑郁发作患者在抗抑郁药物治疗下会出现一定比例的转相。 |
| 英文摘要: |
| Objective To observe prospectively of switching rate of antidepressants in management of depressive episode. Meth-ods 190 patients with depressive episode treated by antidepressants were observed for 3 months and switching rate were assessed under psychiatrist selection without limitation . Results ①18 of 190 patients was found to switch in 3 month therapy. The switching rate was 9. 47%. ②There is no significant difference in switching rate between the male and the female(6. 56%,10. 85%,χ2 =0. 89,P>0. 05).③There is no significant difference in switching rate between unipolar depression and bipolar depression(5. 88%,40%,χ2 =24. 29,P<0. 01).④ There is no significant difference in switching rate between patients token mood stabilizer and patients not token mood stabilizer(13. 8%,8. 44%,χ2 =1. 47,P>0. 05). ⑤There is no significant difference in switching rate between patients token more two antidepressants and patients token single antidepressant(12. 96%,8. 08%,χ2 =1. 07,P>0. 05). ⑥There is no significant difference in switching rate between patients with family history of mood disorder and patients without family history of mood disorder (18. 4%,7. 23%,χ2 =4. 43,P<0. 05).⑦The switching often carry out at one month after treatment with antidepressants. ⑧The sig-nificant difference in switching rate among various antidepressants were not found. Conclusion Some depressive patients may switch during treatment with antidepressant. |
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