| 孔维星,李功迎.神经酰胺与抑郁症的相关性研究进展[J].四川精神卫生杂志,2019,32(1):74-77.,Progress in the study of the correlation between ceramide and depression[J].SICHUAN MENTAL HEALTH,2019,32(1):74-77 |
| 神经酰胺与抑郁症的相关性研究进展 |
| Progress in the study of the correlation between ceramide and depression |
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| DOI：10.11886/j.issn.1007-3256.2019.01.017 |
| 中文关键词: 神经酰胺 酸性鞘磷脂酶 抑郁症 |
| 英文关键词:Ceramide Acid sphingomyelinase Depression |
| 基金项目:国家自然科学基金项目(81571334)；山东省自然科学基金(ZR2011HM023)；山东省研究生教育创新计划项目（SDYY15012)；山东省本科高校教学改革研究项目(2015M049) |
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| 中文摘要: |
| 【摘要】 抑郁症病因至今尚未完全阐明，越来越多的证据表明神经酰胺参与细胞存活、增殖、分化、凋亡等基础生命过程，突破以往惰性脂质的观点，目前神经酰胺作为活跃的第二信使引起广泛关注，其可能是联络抑郁症中枢脑功能损伤与外周炎症、氧化应激之间的重要环节。 然而，神经酰胺与抑郁症之间的确切关联机制尚不明确，本文通过对神经酰胺与抑郁症相关的研究进展进行综述，为抑郁症病因的探索提供新思路。 |
| 英文摘要: |
| The etiology of depression has not been fully elucidated. There is an increasing evidence that ceramide is involved in cell survival, proliferation, differentiation, apoptosis and other basic life processes, which break through the previous view of inert lipid. At present, ceramide, as an active second messenger, may be an important link between central brain dysfunction, peripheral inflammation and oxidative stress in depression. However, the exact relationship between ceramide and depression is not clear. This paper reviewed the progress of ceramide and depression research, and provided a new idea to explore the etiology of depression. |
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