张光勇,王荣科,周豪.低频重复经颅磁刺激对酒依赖患者急性戒断后焦虑、抑郁和复饮的效果[J].四川精神卫生杂志,2019,32(4):342-345.
低频重复经颅磁刺激对酒依赖患者急性戒断后焦虑、抑郁和复饮的效果
Efficacy of low-frequency repetitive transcranial magnetic stimulation on anxiety, depression and relapse in alcohol dependence patients after acute withdrawal
投稿时间:2018-12-14  
DOI:10.11886/j.issn.1007-3256.2019.04.011
中文关键词:  低频重复经颅磁刺激  酒依赖  焦虑  抑郁  复饮
英文关键词:Low-frequency repetitive transcranial magnetic stimulation  Alcohol-dependent  Anxiety  Depression  Drinking relapse
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作者单位
张光勇 绵阳市第三人民医院·四川省精神卫生中心 
王荣科 绵阳市第三人民医院·四川省精神卫生中心 
周豪 绵阳市第三人民医院·四川省精神卫生中心 
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中文摘要:
      【摘要】 目的 探讨低频重复经颅磁刺激(rTMS)对酒依赖急性戒断后焦虑、抑郁和复饮的疗效,为改善酒依赖患者预后提供参考。方法 选取在绵阳市第三人民医院住院的、符合《国际疾病分类(第10版)》(ICD-10)酒精依赖诊断标准的急性戒断后的102例患者为研究对象。采用随机数字表法分为研究组(n=50)和对照组(n=52)。两组患者均接受常规治疗,研究组加用rTMS,对照组应用伪刺激,治疗共8周。于治疗前和治疗第2、4、8周末进行汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表17项版(HAMD-17)评定,在患者出院后3、6月末评定其复饮情况。结果 治疗第2、4、8周末,研究组HAMA和HAMD-17评分均低于治疗前(P均<0.01),且研究组均低于对照组,差异均有统计学意义(P均<0.01);在患者出院后3、6月末,研究组复饮率均低于对照组(P均<0.05)。结论 低频rTMS可能有助于改善酒依赖患者急性戒断后的焦虑、抑郁情绪和复饮情况。
英文摘要:
      Objective To explore the efficacy of low-frequency repetitive transcranial magnetic stimulation (rTMS) on anxiety, depression and relapse after acute withdrawal of alcohol dependence patients, and to provide references for improving the prognosis of patients with alcohol dependence.Methods A total of 102 alcohol dependence inpatients from The Third Hospital of Mianyang who met the International Classification of Diseases, tenth edition (ICD-10) of alcohol dependence after acute withdrawal were enrolled, and divided into the study group (n=50) and control group (n=52) by random number table method. Both groups received conventional treatment, and the study group received rTMS, while the control group received Sham rTMS. During 8 weeks of continuous treatment,patients were assessed by Hamilton Depression Scale-17 item (HAMD-17) and Hamilton Anxiety Scale (HAMA) at the 2nd, 4th and 8th weekend of treatment. After discharge, relapse was also assessed.Results Compared with those before treatment, HAMA and HAMD-17 scores at the 2nd, 4th and 8th weekend of treatment of the study group were decreased (P<0.01), and lower than those of the control group (P<0.01). At the end of the 3rd and 6th month after discharge, the relapse rate of study group were lower than those of the control group (P<0.05).Conclusion Low-frequency rTMS may ameliorate the anxiety, depression and relapse in patients with alcohol dependence after acute withdrawal.
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