王军,马元业,魏长礼,尹雪梅,马忠梅.米安色林治疗抑郁症的效果及对睡眠质量的影响[J].四川精神卫生杂志,2019,32(5):418-421.
米安色林治疗抑郁症的效果及对睡眠质量的影响
Effect of mianserin on symptoms of depression and sleep quality
投稿时间:2018-12-04  
DOI:10.11886/j.issn.1007-3256.2019.05.007
中文关键词:  抑郁症  睡眠障碍  米安色林  帕罗西汀
英文关键词:Depression disorder  Sleep disorders  Mianserin  Paroxetine
基金项目:
作者单位邮编
王军 天水市第三人民医院 741000
马元业 天水市第三人民医院 741000
魏长礼 天水市第三人民医院 741000
尹雪梅 武威市红十字会精神病医院 733000
马忠梅 武威市红十字会精神病医院 733000
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中文摘要:
      目的 探讨米安色林治疗抑郁症的效果及对睡眠的影响,为临床用药选择提供参考。方法 选取2017年5月-2018年2月在天水市第三人民医院和武威市红十字会精神病医院就诊的,符合《国际疾病分类(第10版)》(ICD-10)诊断标准的首发或复发抑郁症患者60例作为研究对象,采用随机数字表法分为米安色林组(n=29)和帕罗西汀组(n=31),分别给予米安色林和帕罗西汀治疗6周。采用汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表24项版(HAMD-24)评定焦虑和抑郁情况,采用副反应量表(TESS)评定安全性。结果 治疗后,米安色林组有效率为79.3%,帕罗西汀组为80.0%,差异无统计学意义(P=0.948)。治疗第1、2周末,两组HAMD-24睡眠因子评分差异有统计学意义[(0.70±0.61)分vs.(1.15±0.88)分,t=-2.17,P=0.035]和[(0.37±0.57)分vs.(0.81±0.85)分,t=-2.22,P=0.031]。两组不良反应发生率差异无统计学意义(79.3% vs. 80.0%,χ2=0.004,P>0.05)。结论 米安色林治疗抑郁症的效果与帕罗西汀相当,但可能更适用于伴睡眠问题的抑郁症患者。
英文摘要:
      Objective To investigate the effect of mianserin on symptoms of depression and sleep quality, and to provide references for related clinical drug selection.Methods Based on the International Classification of Diseases, tenth edition (ICD-10), a total of 60 patients with first or recurrent depression in the Third Hospital of Tianshui and Wuwei Red Cross Psychiatric Hospital from May 2017 to February 2018 were selected, and were divided into the mianserin group (n=29) and paroxetine group (n=31) by random number table method. After continuous treatment of 6 weeks, the clinical efficacy and adverse reactions were assessed with Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale-24 item (HAMD-24) and Treatment Emergent Symptom Scale (TESS).Results After treatment, the effective rate of the mianserin group showed no significant difference with that of the paroxetine group (79.3% vs. 80.0%, P=0.948). The scores of the sleep factor in HAMD-24 at the 1st and 2nd weekend of treatment showed significant difference between the two groups [(0.70±0.61) vs. (1.15±0.88), t=-2.17, P=0.035], [(0.37±0.57) vs. (0.81±0.85), t=-2.22, P=0.031]. There was no statistically significant difference in the incidence of adverse reaction between the two groups (79.3% vs. 80.0%, χ2=0.004, P>0.05).Conclusion The efficacy of mianserin and paroxetine in treating depression is similar, but mianserin may be more appropriate for patients with sleep problems.
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