杨静,程宇琪,姜红燕,罗雄剑,陈娴瑜,沈宗霖,周聪,许秀峰.GRIA1、GRM3、TCF4基因单核苷酸多态性与精神分裂症的关联研究[J].四川精神卫生杂志,2019,32(6):501-505.
GRIA1、GRM3、TCF4基因单核苷酸多态性与精神分裂症的关联研究
Association between single nucleotide polymorphisms ofGRIA1, GRM3, TCF4 genes and schizophrenia
投稿时间:2019-03-26  
DOI:10.11886/scjsws20190326001
中文关键词:  精神分裂症  GRIA1  GRM3  TCF4  单核苷酸多态性
英文关键词:Schizophrenia  GRIA1  GRM3  TCF4  Single nucleotide polymorphisms
基金项目:国家自然科学基金 81660237 ; 云南省应用基础研究(昆医联合专项)[2017FE468(-176)] ; 昆明医科大学第一附属医院重大精神疾病研究省创新团队 2017HC004 国家自然科学基金(81660237);云南省应用基础研究(昆医联合专项)[2017FE468(-176)];昆明医科大学第一附属医院重大精神疾病研究省创新团队(2017HC004)
作者单位E-mail
杨静 昆明医科大学第一附属医院  
程宇琪 昆明医科大学第一附属医院  
姜红燕 昆明医科大学第一附属医院  
罗雄剑 中国科学院大学昆明动物所  
陈娴瑜 昆明医科大学第一附属医院  
沈宗霖 昆明医科大学第一附属医院  
周聪 昆明医科大学第一附属医院  
许秀峰 昆明医科大学第一附属医院 xfxu2004@sina.com 
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中文摘要:
      目的 探讨GRIA1、GRM3和TCF4基因单核苷酸多态性与精神分裂症的关联,为精神分裂症的遗传学研究提供参考。 方法 选取昆明医科大学第一附属医院精神科的663例符合《精神障碍诊断与统计手册(第4版)》(DSM-IV)诊断标准的精神分裂症患者为病例组,以昆明市第一人民医院体检中心的690例健康人为对照组,使用SNaPshot基因分型方法对受试者GRIA1、GRM3、TCF4三个候选基因12个SNPs进行基因分型,并进行遗传学分析。 结果 GRM3多态性位点rs6465084的A等位基因频率与对照组相比差异有统计学意义(P=0.027);以性别特异性做相关分析,表明多态性位点rs6465084 A等位基因频率在男性精神分裂症患者与正常对照组中差异有统计学意义(P=0.02)。 结论 GRM3多态性位点rs6465084可能与精神分裂症存在关联,其等位基因A可能增加精神分裂症的发病风险。
英文摘要:
      Objective To explore the relationships between three candidate functional genes (GRIA1, GRM3 and TCF4) and schizophrenia, and to provide references for genetic research of schizophrenia. Methods A total of 663 schizophrenia patients in the psychiatry department of the First Affiliated Hospital of Kunming Medical University who met the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) were selected as the research group, meanwhile, 690 healthy individuals in the physical examination center of the First Hospital of Kunming were set as the control group. 12 single nucleotide polymorphisms (SNPs) of three candidate functional genes were genotyped by the SNaPshot assay, and the genetic analysis was also performed. Results The A allele frequency of GRM3 SNP rs6465084 in the research group was significantly different from that of the control group (P=0.027). Gender-specific correlation analysis revealed that A allele frequency of SNP rs6465084 had statistic difference between male patients in research group and control group (P=0.02). Conclusion The SNP rs6465084 of GRM3 may be associated with the schizophrenia, and its A allele may increase the risk of schizophrenia.
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