李雪,马会,张冠禹,李武.奥氮平联合利培酮致抗利尿激素分泌紊乱综合征1例[J].四川精神卫生杂志,2020,33(2):180-182.Li Xue,Ma Hui,Zhang Guanyu,Li Wu,Olanzapine combiend with risperidone-induced syndrome of inappropriate antidiuretic hormone secretion: a case report[J].SICHUAN MENTAL HEALTH,2020,33(2):180-182

奥氮平联合利培酮致抗利尿激素分泌紊乱综合征1例

Olanzapine combiend with risperidone-induced syndrome of inappropriate antidiuretic hormone secretion: a case report

投稿时间：2019-08-26

DOI：10.11886/scjsws20190826002

中文关键词: 奥氮平利培酮抗利尿激素分泌紊乱综合征

英文关键词:Olanzapine Risperidone Syndrome of inappropriate antidiuretic hormone secretion

基金项目:

作者	单位	邮编
李雪	济宁医学院精神卫生学院，山东济宁 272067	272067
马会	济宁市精神病防治院，山东济宁 272051	272051
张冠禹	济宁医学院临床医学院，山东济宁 272113	272113
李武	济宁市精神病防治院，山东济宁 272051	272051

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中文摘要:

抗利尿激素分泌紊乱综合征在临床实践中较罕见，尤其是药源性抗利尿激素分泌紊乱综合征需要引起医生的关注。本文报告了1例奥氮平联合利培酮所致抗利尿激素分泌紊乱综合征病例，提示对于长期使用抗精神病药物的患者，精神科医生应注意对电解质的监测，尤其是钠离子，当出现药源性抗利尿激素分泌紊乱综合征时，要及时停药、换药，并补充浓盐液体支持治疗。

英文摘要:

In clinical practice, syndrome of inappropriate antidiuretic hormone secretion is relatively rare, while drug-induced disease still needs to be concerned. This paper reports a case of olanzapine combined with risperidone-induced syndrome of inappropriate antidiuretic hormone secretion, and it indicates that psychiatrists should monitor electrolytes, especially sodium ions, in patients on long-term use of antipsychotics. Moreover, countermeasures including drug withdrawal, prescription adjustment and related support treatment are also proposed for the treatment of durg-induced syndrome of inappropriate antidiuretic hormone secretion.

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