宋德胜,李长平,刘媛媛,崔壮,胡良平.生存资料回归模型分析——Cox比例风险假设的图形检验法[J].四川精神卫生杂志,2020,33(2):121-125.Song Desheng,Li Changping,Liu Yuanyuan,Cui Zhuang,Hu Liangping,Analysis of regression model of survival data——the test of the Cox’s proportional hazards assumption[J].SICHUAN MENTAL HEALTH,2020,33(2):121-125
生存资料回归模型分析——Cox比例风险假设的图形检验法
Analysis of regression model of survival data——the test of the Cox’s proportional hazards assumption
投稿时间:2020-03-12  
DOI:10.11886/scjsws20200312003
中文关键词:  生存分析  比例风险假设  SAS软件  Cox回归模型
英文关键词:Survival analysis  Proportional hazards assumption  SAS software  Cox regression model
基金项目:国家自然科学基金项目(项目名称:贝叶斯生存分析方法在肝细胞癌肝移植患者预后预测中的应用研究,项目编号:81803333)
作者单位邮编
宋德胜 天津医科大学公共卫生学院流行病与卫生统计学教研室天津 300070 300070
李长平 天津医科大学公共卫生学院流行病与卫生统计学教研室天津 300070
世界中医药学会联合会临床科研统计学专业委员会北京 100029 
100029
刘媛媛 天津医科大学公共卫生学院流行病与卫生统计学教研室天津 300070 300070
崔壮 天津医科大学公共卫生学院流行病与卫生统计学教研室天津 300070 300070
胡良平 世界中医药学会联合会临床科研统计学专业委员会北京 100029
军事科学院研究生院北京 100850 
100850
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中文摘要:
      本文目的是介绍目前使用图形检验比例风险的常用方法。经典的Cox比例风险回归模型要求生存资料满足比例风险假设,而在临床资料中,这个假设往往并不成立。鉴于此,本文首先阐述了比例风险假设的概念;然后介绍了一些检验比例风险假设是否成立的常用图示方法,主要包括Kaplan-Meier生存曲线图、ln[-ln(St)]生存时间关系图、缩放Schoenfeld残差与时间的关系图、SAS软件PHREG过程中ACCESS语句的PH和RESAMPLE选项产生的模拟路径图;最后,基于SAS软件并通过实例演示上述方法的实现。
英文摘要:
      The purpose of this study was to introduce the current common methods of examining the assumption of proportional hazards using graphs.The classic Cox proportional hazards model requested the assumption of constant proportional hazards, which was often not true in clinical data. Given that, this article firstly interpreted the concept of the assumption of proportional hazards. Then introduced some common methods to test whether the proportional hazards were constant, which including graphical methods (Kaplan-Meier survival curve, plot about ln[-ln(St)] against survival time, scaled Schoenfeld residual against time diagram, simulation path diagram generated by the PH and RESAMPLE options in the ACCESS statement of the PHREG procedure). Finally, the implementation of the above methods in SAS software was demonstrated through an example.
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