张久平,成鑫,张会会,徐萍,金佩莹,柯晓燕.2153例儿少精神科住院患者精神疾病分布及药物使用[J].四川精神卫生杂志,2020,(5):440-445.
2153例儿少精神科住院患者精神疾病分布及药物使用
Distribution characteristics and medication analysis of mental diseases among 2153 children and adolescents hospitalized in psychiatry department
投稿时间:2020-08-10  
DOI:10.11886/scjsws20200810002
中文关键词:  儿童青少年  精神疾病  住院治疗  药物使用
英文关键词:Children and adolescents  Mental disease  Hospitalization  Medication
基金项目:
作者单位邮编
张久平 南京医科大学附属脑科医院儿童心理卫生研究中心江苏 南京 210029 210029
成鑫 南京医科大学附属脑科医院儿童心理卫生研究中心江苏 南京 210029 210029
张会会 南京医科大学附属脑科医院儿童心理卫生研究中心江苏 南京 210029 210029
徐萍 南京市溧水区精神病防治院江苏 南京 211200 211200
金佩莹 南京医科大学附属脑科医院儿童心理卫生研究中心江苏 南京 210029 210029
柯晓燕 南京医科大学附属脑科医院儿童心理卫生研究中心江苏 南京 210029 210029
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中文摘要:
      目的 调查南京脑科医院儿童心理卫生研究中心住院部儿童青少年患者疾病谱的分布以及临床最终治疗方案中药物的选择。方法 对2012年3月-2019年7月在南京脑科医院儿童心理卫生研究中心住院部住院治疗的儿童青少年患者出院时的诊断分类及出院当日药物治疗的种类、剂量等进行回顾性分析。结果 ①共纳入2 153例患者,调查结果显示,最常见的病种分别为精神分裂症及相关谱系障碍(40.8%)、神经发育障碍及其伴发障碍(17.4%)、抑郁障碍(16.6%)。②共2 098例(98.3%)患者的处方中有精神类药物,精神类药物处方频率前5位依次为阿立哌唑677例(32.3%)、舍曲林570例(27.2%)、奥氮平407例(19.4%)、利培酮352例(16.8%)、丙戊酸钠256例(12.2%)。③不同年代药物使用变化趋势分析显示,近3年抗精神病药物的使用频率均低于前4年的使用频率(P<0.05),其余药物在不同年代的使用频率差异无统计学意义(P>0.05)。④儿童组使用阿立哌唑、利培酮的频率高于青少年组(P<0.05),青少年组使用奥氮平、帕利哌酮、喹硫平的频率高于儿童组(P<0.05)。与女性患者相比,男性患者使用利培酮的频率更高(P<0.05),使用阿立哌唑、喹硫平的频率更低(P<0.05)。结论 住院儿童青少年精神疾病患者的药物使用情况随着年代的变迁而不断变化,处方药物的种类与病种、患者年龄、性别及年代密切相关。
英文摘要:
      Objective To investigate the distribution characteristics and medication of mental diseases among 2 153 children and adolescents hospitalized in Child Mental Health Research Center of Nanjing Brain Hospital.Methods A retrospective analysis was conducted on children and adolescents who discharged from Child Mental health Research Center of Nanjing Brain Hospital from March 2012 to July 2019, including the disease types, therapeutic drug types, drug doses, and etc.Results ① A total of 2 153 patients were included, and the most common diseases were schizophrenia and schizophrenia spectrum disorders (40.8%), neurodevelopmental disorders and associated disorders (17.4%), and depressive disorders (16.6%). ② Of the selected patients, 2 098 patients (98.3%) had psychotropic drugs in their prescriptions, and the top five most commonly used psychotropic drugs were aripiprazole 677 cases (32.3%), sertraline 570 cases (27.2%), olanzapine 407 cases (19.4%), risperidone 352 cases (16.8%) and sodium valproate 256 cases (12.2%). ③ 2012-2019 annual comparative analysis showed that the frequency of antipsychotics used in the past three years was lower than that in the previous four years (P<0.05), and no statistically significant difference was found in other drugs (P>0.05). ④ Aripiprazole and risperidone were used more frequently in children group than those in adolescent group (P<0.05), and the usage frequency of olanzapine, paliperidone and quetiapine in adolescent group was higher than those in children group (P<0.05). Compared with female children, male children had a higher usage frequency of risperidone (P<0.05) and a lower usage frequency of aripiprazole and quetiapine (P<0.05).Conclusion The medication of hospitalized children and adolescents with mental diseases changes over time, and the types of prescription drugs are closely related to the disease type, age, gender and times.
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