张校明,程勇鹏,杨鹏,时亚杰,董再全,胡峻梅,郑重.伴暴力攻击行为的精神分裂症患者感觉门控电位P50研究[J].四川精神卫生杂志,2021,(4):332-335.
伴暴力攻击行为的精神分裂症患者感觉门控电位P50研究
Study of P50 sensory gating deficit in schizophrenic patients with violent and aggressive behaviors
投稿时间:2021-06-10  
DOI:10.11886/scjsws20210610001
中文关键词:  精神分裂症  暴力攻击行为  感觉门控电位  P50
英文关键词:Schizophrenia  Violent or aggressive behaviors  Sensory gating  P50 auditory-evoked potential
基金项目:山东省卫生和健康委员会项目(项目名称:伴有攻击或暴力行为的精神分裂症患者感觉门控电位P50研究,项目编号:2015WS0422);济宁市科技局项目(项目名称:伴有攻击或暴力行为的精神分裂症患者事件相关电位研究,项目编号:2000-45)
作者单位邮编
张校明 济宁市精神病防治院山东 济宁 272051 272051
程勇鹏 山东省诸城市精神卫生中心山东 诸城 266200 266200
杨鹏 济宁市精神病防治院山东 济宁 272051 272051
时亚杰 济宁市精神病防治院山东 济宁 272051 272051
董再全 四川大学华西医院四川 成都 610041 610041
胡峻梅 四川大学华西医院四川 成都 610041 610041
郑重 四川大学华西医院四川 成都 610041 610041
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中文摘要:
      目的 探讨伴暴力攻击行为的精神分裂症患者感觉门控电位P50的特异性,为预测患者暴力攻击行为提供客观生物学标志。方法 纳入符合《国际疾病分类(第10版)》(ICD-10)诊断标准的精神分裂症患者135例,根据修订版外显攻击行为量表(MOAS)评分,将患者分为攻击组(n=70)和非攻击组(n=65)。按年龄、性别等匹配原则招募健康对照组(n=60)。采用日本光电公司生产的MEB-9200诱发电位仪对所有受试者行感觉门控电位P50测试。结果 攻击组波幅S2高于非攻击组和健康组,差异均有统计学意义[(9.86±6.04)μV vs. (7.06±3.88)μV,P=0.004;(9.86±6.04)μV vs.(7.82±3.87)μV,P=0.031]。攻击组、非攻击组及健康组中,波幅S2/S1≥0.5者占比分别为72.88%、43.86%和30.00%,攻击组高于非攻击组和健康组,差异均有统计学意义(P均<0.01)。攻击组波幅差(S1-S2)低于非攻击组和健康组,差异均有统计学意义[(4.35±9.39)μV vs.(9.89±8.48)μV,P=0.001;(4.35±9.39)μV vs.(13.42±9.81)μV,P<0.01]。结论 精神分裂症患者暴力攻击行为的发生可能与其特异性的感觉门控功能缺失有关。
英文摘要:
      Objective To assess the specificity of P50 auditory-evoked potential in schizophrenic patients with violent and aggressive behaviors, so as to provide objective biological markers for predicting violent behaviors of schizophrenic patients.Methods A total of135 schizophrenic patients who met the diagnostic criteria of the International Classification of Diseases, tenth edition (ICD-10) were divided into aggressive group (n=70) and non-aggressive group (n=65) according to the assessment results of the Modified Overt Aggression Scale (MOAS), meantime, another 60 healthy individuals matched for age and gender were set as healthy group. Then the P50 auditory-evoked potentials of all selected individuals were measured using EP/EMG system (MEB-9200, Nihon Kohden, Japan).Results Amp S2 of the aggressive group was significantly higher than those of the non-aggressive group and healthy control group, with statistical differences [(9.86±6.04)μV vs. (7.06±3.88)μV, P=0.004; (9.86±6.04)μV vs. (7.82±3.87)μV, P=0.031]. The proportion of S2/S1 ratio ≥0.5 was 72.88%, 43.86% and 30.00% in aggressive group, non-aggressive group and healthy group, which was the highest in aggressive group, with statistical differences (P<0.01). The amplitude difference of P50 (S1-S2) of the aggressive group was lower than those of the non-aggressive group and the healthy control group, the differences were of statistical significance [(4.35±9.39)μV vs.(9.89±8.48)μV, P=0.001; (4.35±9.39)μV vs.(13.42±9.81)μV, P<0.01].Conclusion The violent and aggressive behaviors in schizophrenic patients may be related to the sensory gating deficit.
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