韦臻,余嘉盛,阮中强,阳琼.强迫症患者前瞻记忆缺损程度对SSRIs疗效的预测作用[J].四川精神卫生杂志,2021,(4):336-340.
强迫症患者前瞻记忆缺损程度对SSRIs疗效的预测作用
Predictive role of the degree of prospective memory impairment on treatment response to SSRIs in patients with obsessive-compulsive disorder
投稿时间:2021-05-12  
DOI:10.11886/scjsws20210512001
中文关键词:  强迫症  前瞻记忆  SSRIs  预测疗效
英文关键词:Obsessive-compulsive disorder  Prospective memory  SSRIs  Outcome prediction
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作者单位邮编
韦臻 南方医科大学附属深圳市妇幼保健院广东 深圳 518028
华南师范大学心理学院/心理应用研究中心广东 广州 510631 
510631
余嘉盛 华南师范大学心理学院/心理应用研究中心广东 广州 510631 510631
阮中强 华南师范大学心理学院/心理应用研究中心广东 广州 510631 510631
阳琼 广州医科大学附属脑科医院广东 广州 510370 510370
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中文摘要:
      目的 探究强迫症患者前瞻记忆缺损程度对选择性5-羟色胺再摄取抑制剂(SSRIs)疗效的预测作用。方法 选择符合《精神障碍诊断与统计手册(第4版)》修订版(DSM-IV-TR)强迫症诊断标准的30例强迫症患者为研究对象,对患者进行为期4周的SSRIs药物治疗。采用耶鲁布朗强迫症状量表(Y-BOCS)评定患者治疗前后强迫症状的严重程度,以Y-BOCS总评分减分率评定疗效,并比较患者治疗前后基于事件、基于时间和基于活动的前瞻记忆任务正确率。结果 治疗后,强迫症患者Y-BOCS总评分低于治疗前[(27.07±4.63)分vs.(24.87±5.93)分,F(1,29)=4.984,P=0.033],基于事件和基于时间的前瞻记忆任务正确率高于治疗前[(0.78±0.21)vs.(0.88±0.11),F(1,29)=9.022,P=0.005;(0.81±0.17)vs.(0.91±0.11),F(1,29)=9.063,P=0.005],患者基线基于事件的前瞻记忆任务正确率与Y-BOCS总评分减分率呈正相关(r=0.478,P=0.014),基线基于事件的前瞻记忆水平可正向预测SSRIs疗效(β=0.441,P=0.014)。结论 强迫症患者基线基于事件的前瞻记忆水平可预测SSRIs疗效,前瞻记忆水平越高,SSRIs疗效越好。
英文摘要:
      Objective To explore the predictive role of the degree of prospective memory impairment on the treatment response to Selective Serotonin Reuptake Inhibitors (SSRIs) in patients with obsessive-compulsive disorder.Methods A total of 30 patients with obsessive-compulsive disorder who met the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revision (DSM-IV-TR) were selected, and all patients were treated with SSRIs for 4 weeks. The severity of obsessive-compulsive symptom was assessed using Yale-Brown Obsessive Compulsive Scale (Y-BOCS), and the efficacy was evaluated by the reduction rate of Y-BOCS score. Moreover, the performance of event-based, time-based and activity-based prospective memory tasks were compared before and after treatment.Results After treatment, the total Y-BOCS score of patients was lower than before treatment [(27.07±4.63) vs. (24.87±5.93), F(1,29)=4.984, P=0.033], meantime, the performance of event- and time- based prospective memory tasks was improved [(0.78±0.21) vs. (0.88±0.11), F(1,29)=9.022, P=0.005; (0.81±0.17) vs. (0.91±0.11), F(1,29)=9.063, P=0.005]. Correlation analysis showed that the performance of event-based prospective memory at baseline was positively correlated with the reduction of Y-BOCS score (r=0.478, P=0.014). The event-based prospective memory performance at baseline could positively predict the treatment response to SSRIs treatment in patients (β=0.441, P=0.014).Conclusion The event-based prospective memory function of patients with obsessive-compulsive disorder can positively predict SSRIs treatment outcome, and patients with better prospective memory performance yield better treatment responses.
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