毛怡,袁卓,张光银,沈莉.艾司西酞普兰治疗后抑郁症患者功能磁共振影像学改变的研究进展[J].四川精神卫生杂志,2021,(4):382-386.
艾司西酞普兰治疗后抑郁症患者功能磁共振影像学改变的研究进展
Review of the brain areas activated in fMRI after escitalopram antidepressant treatment inpatients with major depressive disorder
投稿时间:2021-03-07  
DOI:10.11886/scjsws20210307002
中文关键词:  艾司西酞普兰  抑郁症  功能磁共振成像  系统综述
英文关键词:Escitalopram  Major depressive disorder  Functional magnetic resonance imaging  Systematic review
基金项目:天津市科技计划项目(项目名称:“三位一体”疗法治疗抑郁发作的临床疗效评价研究,项目编号:17ZXMFSY00100)
作者单位邮编
毛怡 天津中医药大学第一附属医院国家中医针灸临床医学研究中心天津 300193 300193
袁卓 天津中医药大学第一附属医院国家中医针灸临床医学研究中心天津 300193 300193
张光银 天津中医药大学第一附属医院国家中医针灸临床医学研究中心天津 300193 300193
沈莉 天津中医药大学第一附属医院国家中医针灸临床医学研究中心天津 300193 300193
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中文摘要:
      本文目的是探讨抑郁症患者接受艾司西酞普兰治疗前后大脑功能磁共振激活改变。功能磁共振研究显示,治疗前,抑郁症患者前额叶、扣带回和纹状体等脑区的活动存在异常,前扣带回、背外侧前额叶、丘脑异常激活可预测艾司西酞普兰的疗效。经艾司西酞普兰治疗后,患者部分脑区恢复正常,且脑区激活的改变与症状的改善具有相关性。本文对抑郁症患者治疗前和不同用药时间的脑功能活动以及脑功能活动改变与临床症状的相关性进行综述。
英文摘要:
      The purpose of this paper is to investigate the altered brain areas activated in functional magnetic resonance imaging before and after escitalopram antidepressant treatment in patients with major depressive disorder. Functional magnetic resonance studies showed abnormal activity in brain regions such as prefrontal cortex, cingulate cortex and striatum in patients prior to treatment, meantime, the abnormal activation of anterior cingulate, dorsolateral prefrontal and thalamus reflected the outcomes of escitalopram antidepressant therapy. Following the treatment with escitalopram, the fMRI activation of brain areas returned to normal, and those changes were significantly correlated with the improvement of depressive symptoms. So this paper provides a review of the brain functional activity changes in patients with major depressive disorder before treatment and at different time point of medication, as well as the correlation between altered brain functional activity and clinical symptoms.
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