叶刚,李哲,潘雯,高士更,沈颖颖,刘颖,殷铭,刘果瑞,赵宇,沈建红,杜向东.伴中重度阻塞性睡眠呼吸暂停低通气综合征的抑郁症患者多导睡眠监测特点[J].四川精神卫生杂志,2021,34(5):424-428.Ye Gang,Li Zhe,Pan Wen,Gao Shigeng,Shen Yingying,Liu Ying,Yin Ming,Liu Guorui,Zhao Yu,Shen Jianhong,Du Xiangdong,Characteristics of polysomnography in depression patients complicating moderate-to-severe obstructive sleep apnea hypopnea syndrome[J].SICHUAN MENTAL HEALTH,2021,34(5):424-428
伴中重度阻塞性睡眠呼吸暂停低通气综合征的抑郁症患者多导睡眠监测特点
Characteristics of polysomnography in depression patients complicating moderate-to-severe obstructive sleep apnea hypopnea syndrome
投稿时间:2021-04-07  
DOI:10.11886/scjsws20210407003
中文关键词:  抑郁症  阻塞性睡眠呼吸暂停低通气综合征  多导睡眠监测
英文关键词:Depression  Obstructive sleep apnea hypopnea syndrome  Polysomnography
基金项目:江苏省卫生计生委面上项目(项目名称:经颅直流电刺激联合正念治疗对抑郁障碍急性期后认知功能的疗效研究,项目编号:H2017069);苏州市精神疾病临床医学中心青年科教项目(项目名称:伴非典型特征的抑郁障碍患者过度睡眠特点及其与唾液皮质醇水平的关系,项目编号:gjyy201705);苏州市姑苏卫生人才培养项目(项目名称:经颅直流电刺激对抑郁症患者认知功能、多导睡眠监测及血清BDNF水平影响的临床随访研究,项目编号:GSWS2019070);苏州市2017年度产业技术创新专项(民生科技-医疗卫生应用基础研究【第二批】)项目(项目名称:C-反应蛋白(CRP)对草酸艾司西酞普兰和文拉法辛疗效的预测研究,项目编号:SYSD2017137);苏州市姑苏卫生人才计划(项目名称:抑郁症自杀行为的风险决策认知内表型缺陷及其免疫机制研究,项目编号:GSWS2020097)
作者单位邮编
叶刚 苏州市广济医院江苏 苏州 215137 215137
李哲 苏州市广济医院江苏 苏州 215137 215137
潘雯 苏州市广济医院江苏 苏州 215137 215137
高士更 苏州市广济医院江苏 苏州 215137 215137
沈颖颖 苏州市广济医院江苏 苏州 215137 215137
刘颖 苏州市广济医院江苏 苏州 215137 215137
殷铭 苏州市广济医院江苏 苏州 215137 215137
刘果瑞 苏州市广济医院江苏 苏州 215137 215137
赵宇 苏州市广济医院江苏 苏州 215137 215137
沈建红 苏州市广济医院江苏 苏州 215137 215137
杜向东 苏州市广济医院江苏 苏州 215137 215137
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中文摘要:
      目的 探讨伴中重度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的抑郁症患者多导睡眠监测(PSG)特点。方法 回顾性分析2017年12月-2019年10月在苏州市广济医院睡眠医学中心完成整夜多导睡眠监测(PSG)的门诊和住院患者以及健康体检人群,从中筛选出四组被试,分别为伴中重度OSAHS的抑郁症患者(n=31)、不伴OSAHS的抑郁症患者(n=79)、中重度OSAHS患者(n=96)和正常对照组(n=32)。比较四组被试睡眠进程相关指标(总睡眠时间、睡眠潜伏期、觉醒次数)和睡眠结构相关指标(N1、N2、N3期及REM期占总睡眠时间的比例,REM潜伏期、REM期持续时间)以及睡眠呼吸相关指标(氧减指数)等参数。结果 睡眠进程方面,四组被试总睡眠时间、睡眠潜伏期和觉醒次数差异均有统计学意义(F=2.874、3.959、12.291,P<0.05或0.01)。睡眠结构方面,四组被试N2期、N3期占总睡眠时间比例差异均有统计学意义(F=13.885、48.013,P均<0.01);四组被试REM潜伏期、REM期持续时间、REM期占总睡眠时间比例差异均有统计学意义(F=41.492、11.827、10.552,P均<0.01)。睡眠呼吸相关指标方面,四组被试氧减指数差异有统计学意义(F=170.585,P<0.05)。结论 伴中重度OSAHS的抑郁症患者存在严重的睡眠进程和结构紊乱,同时伴有更频繁和更严重的呼吸相关事件。
英文摘要:
      Objective To investigate the characteristics of polysomnography (PSG) in depression patients complicating moderate-to-severe obstructive sleep apnea hypopnea syndrome (OSAHS).Methods A retrospective analysis was conducted on the outpatients, inpatients and physical examination population who completed overnight PSG monitoring in the sleep medicine center of Suzhou Guangji Hospital from December 2017 to October 2019. Four groups of subjects were finally enrolled, including depression patients with moderate-to-severe OSAHS (n=31), depression patients without OSAHS (n=79), moderate-to-severe OSAHS patients (n=96) and normal control group (n=32). The sleep process related indicators (total sleep time, sleep latency, number of awakenings), sleep structure related indicators (N1, N2, N3, percentage of REM sleep, REM latency, REM sleep duration), sleep-related respiratory variables (oxygen reduction index) and other polysomnographic parameters of the four groups were compared.Results In terms of sleep process, the total sleep time, sleep latency and number of awakenings yielded significant differences among the four groups (F=2.874, 3.959, 12.291, P<0.05 or 0.01). In terms of sleep structure, the percentage of total sleep time in N2 and N3 stages demonstrated significant differences among the four groups (F=13.885, 48.013, P<0.01). The REM latency, REM sleep duration and percentage of REM sleep manifested significant differences among the four groups (F=41.492, 11.827, 10.552, P<0.01). In terms of sleep-related respiratory variables, the oxygen reduction index exhibited significant differences among the four groups (F=170.585, P<0.05).Conclusion Depression patients complicating moderate-to-severe OSAHS suffer from severe sleep process and structural disturbances, accompanied by quite frequent and severe sleep-related respiratory events.
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