| 胡少华.难治性抑郁症及其诊断治疗[J].四川精神卫生杂志,2022,35(1):1-5.Hu Shaohua,Treatment-resistant depression and its diagnosis and treatment[J].SICHUAN MENTAL HEALTH,2022,35(1):1-5 |
| 难治性抑郁症及其诊断治疗 |
| Treatment-resistant depression and its diagnosis and treatment |
| 投稿时间：2021-10-22 |
| DOI：10.11886/scjsws20211022002 |
| 中文关键词: 难治性抑郁症 定义 诊断 治疗 |
| 英文关键词:Treatment-resistant depression Definition Diagnosis Treatment |
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| 中文摘要: |
| 本文目的是探讨难治性抑郁症（TRD），尤其是不同治疗策略及其选择。尽管抗抑郁药物的疗效已十分确切，但临床中仍有20%~30%的抑郁症患者经抗抑郁药规范治疗后无效或效果不佳，TRD治疗成本更高，疾病负担更重。本文从定义、患病率、疾病负担、病因学机制、危险因素、评估分级、鉴别诊断以及治疗等方面展开探讨，重点阐述不同治疗策略及其选择，以期为TRD的临床实践和科学研究提供参考。 |
| 英文摘要: |
| The aim of this study is to explore the diagnostic strategies and options for treatment-resistant depression （TRD）. Despite the well-established efficacy of antidepressants， 20%~30% of depressive patients in the clinic fail to respond or respond poorly to normative treatment with antidepressants. Patients with TRD are forced to bear a heavy burden of medical costs and disease. Therefore， this article discusses the TRD in terms of the definition， prevalence， disease burden， etiological mechanism， risk factors， assessment grading， highlighting different treatment strategies and options to inform clinical practice and scientific research on TRD. |
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