| 乞盟,孟繁蕾,宋天贺,王停停,刘锦梦,周双浆,陈景旭.伴失眠的缓解期抑郁症患者客观睡眠质量与认知功能的关系[J].四川精神卫生杂志,2022,35(2):126-131.Qi Meng,Meng Fanlei,Song Tianhe,Wang Tingting,Liu Jinmeng,Zhou Shuangjiang,Chen Jingxu,Relationship between objective sleep quality and cognitive function in remission depression patients with insomnia[J].SICHUAN MENTAL HEALTH,2022,35(2):126-131 |
| 伴失眠的缓解期抑郁症患者客观睡眠质量与认知功能的关系 |
| Relationship between objective sleep quality and cognitive function in remission depression patients with insomnia |
| 投稿时间：2021-11-21 |
| DOI：10.11886/scjsws20211121002 |
| 中文关键词: 抑郁症 失眠 睡眠质量 认知功能 缓解期 |
| 英文关键词:Depression Insomnia Sleep quality Cognitive function Remission |
| 基金项目:北京市医院管理中心临床医学发展专项经费（项目名称：网络化失眠认知行为疗法干预缓解期抑郁症失眠的应用研究，项目编号：XMLX202150） |
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| 中文摘要: |
| 目的 探讨伴失眠的缓解期抑郁症患者客观睡眠质量与认知功能的关系。方法 在北京回龙观医院筛选缓解期抑郁症患者47例，采用失眠严重程度指数量表（ISI）和匹兹堡睡眠质量指数量表（PSQI）前四项计算的睡眠效率对患者进行分组，最终伴失眠组22例，不伴失眠组25例。通过多导睡眠监测（PSG）评定患者客观睡眠情况，采用重复性成套神经心理状态测验（RBANS）评定患者认知功能。建立回归模型探究伴失眠的缓解期抑郁症患者客观睡眠质量与认知功能的关系。结果 伴失眠与不伴失眠的缓解期抑郁症患者RBANS即刻记忆因子评分差异有统计学意义（t=-2.102，P<0.05）。伴失眠组的睡眠效率（Z=-2.113，P<0.05）、N3期占比（Z=-3.175，P<0.01）和N3期持续时间（Z=-3.196，P<0.01）均小于不伴失眠组，夜间总清醒时间（Z=-2.058，P<0.05）、N1期占比（Z=-2.399，P<0.05）和N1期持续时间（Z=-2.463，P<0.05）均多于不伴失眠组。伴失眠组REM期占比增加与注意功能的改善相关（β=0.953，95% CI：0.123~2.038，P<0.05），夜间总清醒时间增加与延迟记忆的下降相关（β=-0.173，95% CI：-0.325~-0.024，P<0.05）。结论 伴失眠的缓解期抑郁症患者客观睡眠和认知功能损害存在关联，REM期占比对注意功能产生正向影响，夜间总清醒时间过长对延迟记忆存在负向影响。 |
| 英文摘要: |
| Objective To discuss the relationship between objective sleep quality and cognitive function in remission depression patients with insomnia.Methods A total of 47 patients with depression in remission in Beijing Huilongguan Hospital were enrolled. Insomnia Severity Index （ISI） and the sleep efficiency calculated by the first four items of Pittsburgh Sleep Quality Index （PSQI） were defined as insomnia. Among the selected patients， 22 subjects were classified into insomnia group， and 25 subjects in non-insomnia group. The objective sleep status of all subjects was evaluated by polysomnography （PSG）， and the cognitive function was evaluated with the Repeatable Battery for Assessment of Neuropsychological Status （RBANS）. A regression model was established to explore the relationship between objective sleep quality and cognitive function in remission depression patients with insomnia.Results There was statistically significant difference in immediate memory factor scores of RBANS between depression patients in remission with and without insomnia （t=-2.102， P<0.05）. The sleep efficiency （Z=-2.113， P<0.05）， the proportion of N3 sleep stage （Z=-3.175， P<0.01） and the duration of N3 sleep stage （Z=-3.196， P<0.01） in insomnia group were all lower than those in non-insomnia group， and the nocturnal awakening （Z=-2.058， P<0.01）， the proportion of N1 sleep stage （Z=-2.399， P<0.05） and the duration of N1 sleep stage （Z=-2.463， P<0.05） were higher than those of the insomnia group. Within insomnia group， the increased proportion of REM sleep was correlated with the improvement of attention function （β=0.953， 95% CI： 0.123~2.038， P<0.05）， and the increase of nocturnal awakening was correlated with the decline of delayed memory （β=-0.173， 95% CI： -0.325~-0.024， P<0.05）.Conclusion Objective sleep is associated with cognitive impairment in remission depression patients with insomnia， the proportion of REM sleep has a positive impact on attention function， and frequent nocturnal awakening at night has a negative impact on delayed memory. |
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