| 岳磊,朱秀梅,何诗静,严少菁.不同性别精神障碍患者尿路感染病原菌差异分析[J].四川精神卫生杂志,2022,35(3):245-249.Yue Lei,Zhu Xiumei,He Shijing,Yan Shaojing,Analysis of pathogenic bacteria of urinary tract infection in patients with mental disorders of different genders[J].SICHUAN MENTAL HEALTH,2022,35(3):245-249 |
| 不同性别精神障碍患者尿路感染病原菌差异分析 |
| Analysis of pathogenic bacteria of urinary tract infection in patients with mental disorders of different genders |
| 投稿时间：2021-11-16 |
| DOI：10.11886/scjsws20211116002 |
| 中文关键词: 精神科 尿路感染 抗生素 耐药性 |
| 英文关键词:Psychiatry department Urinary tract infection Antibiotic Drug resistance |
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| 中文摘要: |
| 目的 分析广州市某医院不同性别的精神障碍住院患者尿路感染病原菌分布及药敏试验结果的差异，为临床诊疗过程中合理用药提供参考。方法 回顾分析2019年-2020年广州市某医院住院精神障碍患者尿路感染的临床病例资料，共326例，其中男性126例，女性200例。收集患者性别、年龄、尿液培养的细菌鉴定及药敏试验结果等数据。分析不同性别的患者尿路感染病原菌的细菌分布及耐药率的差异。结果 共分离出尿路感染细菌326株，其中多重耐药菌103株（31.60%）。男性和女性患者尿路感染多重耐药菌分别为52株（41.27%）和51株（25.50%），男性患者尿路感染的多重耐药菌分离率高于女性患者，差异有统计学意义（χ2=8.895，P<0.01）。细菌分布方面，女性患者大肠埃希菌构成比高于男性患者（χ2=14.794），而鲍曼不动杆菌和铜绿假单胞菌的构成比低于男性患者（χ2=13.665、4.054），差异均有统计学意义（P<0.05或0.01）。药敏试验结果显示，女性患者组中分离出的大肠埃希菌对氨苄西林/舒巴坦、氨曲南、头孢吡肟、头孢他啶、左旋氧氟沙星、亚胺培南和美罗培南等多种抗生素的耐药率均低于男性患者组，差异均有统计学意义（χ2=5.028~17.680，P<0.05或0.01）。结论 不同性别的住院精神障碍患者尿路感染的发病率和细菌分布存在差异，女性患者大肠埃希菌的耐药率低于男性患者。 |
| 英文摘要: |
| Objective To analyze the gender differences in the pathogen distribution and drug susceptibility of bacteria causing urinary tract infection among psychiatric inpatients in a hospital in Guangzhou， and to provide a basis for clinical diagnosis and rational use of drugs in treatment.Methods Clinical data of 326 psychiatric patients complicating urinary tract infection in a hospital in Guangzhou from 2019 to 2020 were retrospectively analyzed， including 126 males and 200 females. Data including gender， age， identification results of urinary tract pathogens from urine samples and drug susceptibility results were collected. The differences in bacterial distribution and drug resistance rate of urinary tract infection pathogens in patients of different genders were analyzed.Results A total of 326 strains of urinary tract infection bacteria were isolated， including 103 strains （31.60%） of multi-drug resistant bacteria. Male and female urinary tract infection in patients with multi-drug resistant bacteria were detected 52 strains （41.27%） and 51 strains （25.50%）， the detection rate of multi-drug resistant bacteria in female patients was significantly higher than that in male patients， with statistical difference （χ2=8.895， P<0.01）. In terms of bacterial distribution， the composition ratio of Escherichia coli in female patients was higher than that in male patients （χ2=14.794）， while the composition ratio of Acinetobacter baumannii and Pseudomonas aeruginosa was lower than that in male patients （χ2=13.665， 4.054）， with statistical difference （P<0.05 or 0.01）. The drug susceptibility results showed that Escherichia coli isolated from female patients were less resistant to various antibiotics such as ampicillin/sulbactam， aztreonam， cefepime， ceftazidime， levofloxacin， imipenem and meropenem than those from male patients （χ2=5.028~17.680， P<0.05 or 0.01）.Conclusion The prevalence rate and bacterial distribution of psychiatric patients complicating urinary tract infection differ between patients of different genders， furthermore， the rate of drug resistance for Escherichia coli is lower in female patients than that in male patients. |
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