| 郑财济,沈小丹,李裕基.精神分裂症合并肺结核患者用药监护1例[J].四川精神卫生杂志,2022,35(6):577-579.Zheng Caiji,Shen Xiaodan,Li Yuji,Pharmaceutical care for patient with schizophrenia combined with pulmonary tuberculosis： a case report[J].SICHUAN MENTAL HEALTH,2022,35(6):577-579 |
| 精神分裂症合并肺结核患者用药监护1例 |
| Pharmaceutical care for patient with schizophrenia combined with pulmonary tuberculosis： a case report |
| 投稿时间：2022-05-07 |
| DOI：10.11886/scjsws20220507001 |
| 中文关键词: 精神分裂症 肺结核 氯氮平 利福平 |
| 英文关键词:Schizophrenia Pulmonary tuberculosis Clozapine Rifampicin |
| 基金项目:广东省高水平临床重点专科（深圳市配套建设经费）资助（项目编号：SZGSP013） |
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| 中文摘要: |
| 本文报道1例精神分裂症合并肺结核患者接受氯氮平联合利福平治疗，因利福平具有肝药酶诱导作用，氯氮平血药浓度无法达到有效浓度，患者仍存在被害妄想等精神症状，停用利福平后，氯氮平血药浓度在有效浓度范围内，患者精神症状改善。通过分析精神分裂症合并肺结核患者的治疗方案，本案例提示氯氮平与利福平可能存在相互作用，以期为此类患者的治疗提供参考。 |
| 英文摘要: |
| This paper reported a case of schizophrenia combined with pulmonary tuberculosis treated with clozapine in combination with rifampicin. Due to the induction of hepatic drug enzyme of rifampicin， plasma concentration of clozapine could not reach the effective concentration and the patient still had psychotic symptoms such as persecutory delusion. After discontinuation of rifampicin， plasma concentration of clozapine were in the effective concentration range and the patient's psychiatric symptoms improved. By analysing the therapeutic regimen for the patient with schizophrenia combined with pulmonary tuberculosis， this case suggested a possible interaction between clozapine and rifampin， and provided a reference for the treatment of this type of patients. |
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