| 蓝贤俊,覃振捐,刘其蔓,蔡东滨,卢姚姚,黄雄,郑伟.甜梦口服液治疗抗精神病药物所致女性精神分裂症患者高泌乳素血症效果和安全性的Meta分析[J].四川精神卫生杂志,2023,36(1):25-31.Lan Xianjun,Qin Zhenjuan,Liu Qiman,Cai Dongbin,Lu Yaoyao,Huang Xiong,Zheng Wei,Efficacy and safety of Tianmeng Oral Liquid in the treatment of hyperprolactinemia caused by antipsychotics in female patients with schizophrenia： a Meta-analysis[J].SICHUAN MENTAL HEALTH,2023,36(1):25-31 |
| 甜梦口服液治疗抗精神病药物所致女性精神分裂症患者高泌乳素血症效果和安全性的Meta分析 |
| Efficacy and safety of Tianmeng Oral Liquid in the treatment of hyperprolactinemia caused by antipsychotics in female patients with schizophrenia： a Meta-analysis |
| 投稿时间：2022-10-18 |
| DOI：10.11886/scjsws20221018001 |
| 中文关键词: 甜梦口服液 精神分裂症 高泌乳素血症 Meta分析 |
| 英文关键词:Tianmeng Oral Liquid Schizophrenia Hyperprolactinemia Meta-analysis |
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| 中文摘要: |
| 目的 系统评价甜梦口服液治疗抗精神病药物所致女性精神分裂症患者高泌乳素血症的效果和安全性，为抗精神病药物所致高泌乳素血症的干预提供参考。方法 计算机检索英文数据库（PubMed、Cochrane Library、PsycINFO和Embase）和中文数据库（中国知网和万方数据库），检索时限为建库至2022年9月16日，纳入关于甜梦口服液治疗抗精神病药物所致女性精神分裂症患者高泌乳素血症随机对照试验的文献。由3位研究者根据PICOS原则独立筛选文献并提取数据，对纳入文献的方法学进行质量评价，采用RevMan 5.3进行Meta分析。结果 共纳入3篇文献，包括256例伴有高泌乳素血症的女性精神分裂症患者，其中干预组和对照组各128例。Meta分析结果显示，在治疗终点时，干预组高泌乳素血症的改善效果优于对照组（RR=1.73，95% CI：1.07~2.79，P?0.05），干预组血清泌乳素水平低于对照组（WMD=-55.17，95% CI：-68.16~-42.18，P?0.01），干预组阳性和阴性症状量表（PANSS）总评分低于对照组（WMD=-7.36，95% CI：-8.94~-5.77，P?0.01）。结论 甜梦口服液可能有助于改善抗精神病药物所致女性精神分裂症患者高泌乳素血症的临床症状，降低血清泌乳素水平，改善患者的精神病性症状。 |
| 英文摘要: |
| Objective To systematically evaluate the efficacy and safety of Tianmeng Oral Liquid in the treatment of hyperprolactinemia caused by antipsychotics in female patients with schizophrenia， and to provide references for intervention of antipsychotic-induced hyperprolactinemia patients.Methods English databases （PubMed， Cochrane Library， PsycINFO and Embase） and Chinese databases （CNKI and Wanfang） were systematically searched， with a search time frame of the period from database creation to September 16， 2022. Randomized controlled studies （RCTs） on adjunctive Tianmeng Oral Liquid in the treatment of hyperprolactinemia caused by antipsychotics in female patients with schizophrenia were included. Three investigators independently screened the literatures and extracted data according to PICOS principles and evaluated the quality of including literatures， and the Meta-analysis was performed by using RevMan 5.3.Results A total of 3 articles including 256 female schizophrenic patients with hyperprolactinemia were included. Meta-analysis results showed that at the treatment endpoint， the improvement of hyperprolactinemia symptoms reported a significant superiority of the intervention group than the control group （RR=1.73， 95% CI： 1.07~2.79， P?0.05）. Similarly， the significant superiority of the intervention group than the control group were also found in reducing serum prolactin levels （WMD=-55.17， 95% CI： -68.16~-42.18， P<0.01） and Positive and Negative Syndrome Scale （PANSS） total scores were lower in the intervention group than in the control group （WMD=-7.36， 95% CI： -8.94~-5.77， P<0.01）.Conclusion Tianmeng Oral Liquid may help improve clinical efficacy and reduce serum prolactin levels in female schizophrenia patients with hyperprolactinemia. It may improve psychiatric symptoms in female patients with schizophrenia. |
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