| 叶小英,陶卫群,张晴晴,杨颖佳,谢新晖,杨斌让.长期住院的精神分裂症患者糖脂代谢变化轨迹：一项真实世界研究[J].四川精神卫生杂志,2023,36(2):111-117.Ye Xiaoying,Tao Weiqun,Zhang Qingqing,Yang Yingjia,Xie Xinhui,Yang Binrang,Trajectories of glucose and lipid metabolism of schizophrenic patients in long-term hospitalization： a real-world study[J].SICHUAN MENTAL HEALTH,2023,36(2):111-117 |
| 长期住院的精神分裂症患者糖脂代谢变化轨迹：一项真实世界研究 |
| Trajectories of glucose and lipid metabolism of schizophrenic patients in long-term hospitalization： a real-world study |
| 投稿时间：2023-02-18 |
| DOI：10.11886/scjsws20230218003 |
| 中文关键词: 精神分裂症 长期住院患者 糖代谢 脂代谢 真实世界研究 |
| 英文关键词:Schizophrenia Patients in long-term hospitalization Glucose metabolism Lipid metabolism Real-world study |
| 基金项目:广东省高水平临床重点专科（深圳市配套建设经费）资助项目（项目编号：SZGSP013） |
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| 中文摘要: |
| 目的 描绘长期住院的精神分裂症患者糖脂代谢变化轨迹。方法 纳入2014年–2022年在深圳市康宁医院住院、符合《国际疾病分类（第10版）》（ICD-10）精神分裂症诊断标准的患者为研究对象，对患者进行基于真实世界的纵向糖代谢（空腹血糖、糖化血红蛋白、C-肽）和脂代谢（甘油三酯、低密度脂蛋白、高密度脂蛋白、总胆固醇）随访数据的观察。访视频率为每年1次，共随访8年，总访视次数为9次。结果 糖代谢指标方面，空腹血糖水平在第7次访视时降为4.87 mmol/L，低于基线水平（P<0.01）；糖化血红蛋白在第9次访视时为6.08%，高于基线水平（P<0.05）；C-肽水平在第7次访视为3.14 ng/mL，高于基线水平（P<0.01）。脂代谢指标方面，从第2次访视开始，高密度脂蛋白水平均低于基线水平（P均<0.01），其后基本稳定；总胆固醇水平在最后3次访视时分别为4.06、4.07、3.95 mmol/L，均低于基线水平（P均<0.01）。结论 长期住院的精神分裂症患者糖脂代谢指标在8年随访期间的变化总体较平稳。 |
| 英文摘要: |
| Objective To picture the trajectory of changes in glucose and lipid metabolism among schizophrenic patients in long-term hospitalization.Methods A total of 109 inpatients of Shenzhen Kangning Hospital from 2014 to 2022， who were diagnosed with schizophrenia based on the International Classification of Diseases， tenth edition （ICD-10） criteria， were recruited as subjects. Real-world follow-up data on longitudinal glucose metabolism （fasting blood glucose， glycosylated hemoglobin， C-peptide） and lipid metabolism （triglycerides， low density lipoprotein， high density lipoprotein， total cholesterol） were observed. The frequency of visit was once a year， with a total of 9 visits over 8 years.Results In terms of glucose metabolism parameters， fasting blood glucose level decreased to 4.87 mmol/L at the 7th visit， lower than the baseline level （P<0.01）. Glycated hemoglobin level was 6.08% at the 9th visit， higher than the baseline level （P<0.05）. C-peptide level was 3.14 ng/mL at the 7th visit， higher than the baseline level （P<0.01）. As for the trajectory of lipid metabolism parameters， high-density lipoprotein level were significantly lower than baseline level at the second visit （P<0.01） and stayed basically stable thereafter. Total cholesterol levels at the last three visits were 4.06， 4.07 and 3.95 mmol/L， respectively， all lower than the baseline level （P<0.01）.Conclusion The changes of glycolipid metabolism parameters in long-term inpatients with schizophrenia were generally smooth during the 8-year follow-up period. |
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