| 武琦,周奇,张丽,张晓娟,张宏强.中药复方对抗精神病药物所致女性精神分裂症患者闭经的疗效的Meta分析[J].四川精神卫生杂志,2024,37(3):282-288.Wu Qi,Zhou Qi,Zhang Li,Zhang Xiaojuan,Zhang Hongqiang,Efficacy of traditional Chinese medicine compound on amenorrhea in female patients with schizophrenia caused by antipsychotic drugs： a Meta-analysis[J].SICHUAN MENTAL HEALTH,2024,37(3):282-288 |
| 中药复方对抗精神病药物所致女性精神分裂症患者闭经的疗效的Meta分析 |
| Efficacy of traditional Chinese medicine compound on amenorrhea in female patients with schizophrenia caused by antipsychotic drugs： a Meta-analysis |
| 投稿时间：2023-07-18 |
| DOI：10.11886/scjsws20230718001 |
| 中文关键词: 抗精神病药物所致闭经 中药复方 临床疗效 Meta分析 |
| 英文关键词:Antipsychotic-induced amenorrhea Traditional Chinese medicine compound Clinical efficacy Meta-analysis |
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| 中文摘要: |
| 背景 精神疾病发病率不断升高，而抗精神病药物容易引发女性患者药源性闭经，使患者服药依从性降低，疾病复发率增高。改善药物引起的女性患者闭经问题成为一个亟需解决的问题。目的 探讨中药复方治疗抗精神病药物所致闭经的效果和安全性，为中药复方治疗抗精神病药物所致闭经提供参考。方法 于2022年9月4日，计算机检索中国知网、维普数据库、万方数据库、中国生物医学文献数据库、PubMed、Cochrane Library、Embase，收集中药复方治疗抗精神病药物所致闭经的随机对照试验（RCT）。采用Cochrane 5.3偏倚风险评估工具对纳入文献进行质量评价。采用RevMan 5.3对中药复方治疗抗精神病药物所致闭经的总有效率、治愈率、不良反应发生率和复发率进行Meta分析。结果 最终纳入22项RCT研究，包括1 879例患者。Meta分析结果显示，中药复方或中药复方联合西药治疗抗精神病药物所致闭经的总有效率（RR=1.29，95% CI：1.16~1.44）及治愈率（RR=1.62，95% CI：1.45~1.80）均高于单纯西药治疗，不良反应发生率（RR=0.56，95% CI：0.41~0.76）和复发率（RR=0.16，95% CI：0.06~0.42）均低于单纯西药治疗。结论 中药复方可能有助于改善抗精神病药物所致的闭经，且安全性优于单纯西药治疗。 |
| 英文摘要: |
| Background The incidence of mental disorders is steadily increasing. However， antipsychotic medications， commonly used in treatment， can lead to drug-induced amenorrhea in female patients. This side effect significantly reduces medication adherence and increases the risk of disease recurrence. Therefore， addressing drug-induced amenorrhea in female patients has become an urgent problem requiring effective solutions.Objective To explore the efficacy and safety of traditional Chinese medicine compound in treating antipsychotic-induced amenorrhea， so as to provide guidance for the treatment of this condition using traditional Chinese medicine compound.Methods On September 4， 2022， a computerized search was conducted on across multiple databases， including China National Knowledge Infrastructure， VIP Database， Wanfang Database， China Biomedical Literature Database， PubMed， Cochrane Library and Embase， and randomized controlled trials （RCT） of traditional Chinese medicine compound in treating antipsychotic-induced amenorrhea were collected. The quality of the included literature was assessed using Cochrane 5.3 bias risk assessment tool. Meta-analysis was performed to assess the total effective rate， cure rate， incidence of adverse reactions and recurrence rate using RevMan 5.3.Results Ultimately， 22 RCT involving 1 879 patients were included. Meta-analysis results showed that the total effective rate （RR=1.29， 95% CI： 1.16~1.44） and cure rate （RR=1.62， 95% CI： 1.45~1.80） of traditional Chinese medicine compound or its combination with western medicine in treating antipsychotic-induced amenorrhea were significantly higher compared to western medicine alone. Moreover， the incidence of adverse reactions （RR=0.56， 95% CI： 0.41~0.76） and recurrence rate （RR=0.16， 95% CI： 0.06~0.42） were significantly lower than those of western medicine alone.Conclusion Traditional Chinese medicine compound may offer benefits in ameliorating antipsychotic-induced amenorrhea and its safety is better than simple western medicine treatment. |
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