陈旭姝,刘鑫,何昌九,熊朝新宇,郭易,魏泸懿,刘元元,张春熙,刘祥.社区精神分裂症患者负性生活事件与失眠的关系:精神病性症状和抑郁的作用路径[J].四川精神卫生杂志,2024,37(5):439-443.Chen Xushu,Liu Xin,He Changjiu,Xiong Chaoxinyu,Guo Yi,Wei Luyi,Liu Yuanyaun,Zhang Chunxi,Liu Xiang,Relationship between stressful life events and insomnia in community-dwelling patients with schizophrenia: path analysis of psychotic symptoms and depression[J].SICHUAN MENTAL HEALTH,2024,37(5):439-443
社区精神分裂症患者负性生活事件与失眠的关系:精神病性症状和抑郁的作用路径
Relationship between stressful life events and insomnia in community-dwelling patients with schizophrenia: path analysis of psychotic symptoms and depression
投稿时间:2023-10-22  
DOI:10.11886/scjsws20231022002
中文关键词:  负性生活事件  失眠  精神病性症状  抑郁  精神分裂症
英文关键词:Stressful life events  Insomnia  Psychotic symptoms  Depressive disorder  Schizophrenia
基金项目:
作者单位邮编
陈旭姝 成都医学院护理学院四川 成都 610083 610083
刘鑫 成都医学院护理学院四川 成都 610083 610083
何昌九* 成都市第四人民医院四川 成都 610036 610036
熊朝新宇 四川大学华西公共卫生学院四川 成都 610041 610041
郭易 四川大学华西公共卫生学院四川 成都 610041 610041
魏泸懿 四川大学华西公共卫生学院四川 成都 610041 610041
刘元元 四川大学华西公共卫生学院四川 成都 610041 610041
张春熙 四川大学华西公共卫生学院四川 成都 610041 610041
刘祥 四川大学华西公共卫生学院四川 成都 610041 610041
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中文摘要:
      背景 失眠是精神分裂症患者的常见症状。患者经历的负性生活事件、精神病性症状以及抑郁均可能影响失眠。但在社区精神分裂症患者中,四者的关系尚需进一步探讨。目的 探讨负性生活事件对社区精神分裂症患者失眠的影响以及精神病性症状与抑郁的作用路径,以期为社区精神分裂症患者失眠的干预提供参考。方法 于2023年4月—6月,纳入四川省成都市48个社区卫生服务中心在管的、符合《国际疾病分类(第10版)》(ICD)精神分裂症诊断标准的1 105例患者。采用10项负性生活事件(SLEs)、阿斯森失眠量表(AIS)、精神病筛查问卷(PSQ)、患者健康问卷抑郁量表(PHQ-9)进行评定。采用Spearman相关分析考查各量表评分之间的相关性,采用Smart PLS 4.0构建中介模型,采用偏最小二乘法和Bootstrap法检验中介效应。结果 检出332例(30.05%)社区精神分裂症患者存在失眠。精神分裂症患者AIS评分与SLEs评分、PSQ评分、PHQ-9评分均呈正相关(r=0.165、0.322、0.554,P均<0.01)。精神病性症状和抑郁可能是社区精神分裂症患者负性生活事件与失眠之间的独立作用路径,间接效应值分别为0.102、0.372,效应量分别为10.46%、38.15%。精神病性症状和抑郁可能是社区精神分裂症患者负性生活事件与失眠之间的链式作用路径,间接效应值为0.190,效应量为19.49%。结论 社区精神分裂症患者的负性生活事件可以直接影响失眠,也可以通过精神病性症状和抑郁的独立或链式作用路径影响失眠。
英文摘要:
      Backgrounds Insomnia is frequent in schizophrenia and is found to be negatively affected by stressful life events, psychotic symptoms and depressive disorder, while the relationship among the four remains understudied in community-dwelling patients with schizophrenia.Objective To analyze the effect of stressful life events on insomnia in community-dwelling patients with schizophrenia, and to explore the mediation effect of psychotic symptoms and depression, so as to provide references for the intervention of insomnia in community-dwelling patients with schizophrenia.Methods From April to June 2023, a sample of 1 105 patients with schizophrenia attending 48 community health centers in Chengdu, Sichuan province and fulfilling the International Classification of Diseases, tenth edition (ICD-10) diagnostic criteria were included. All subjects were assessed using Stressful Life Event Scale (SLEs), Athens Insomnia Scale (AIS), Psychosis Screening Questionnaire (PSQ), and Patient Health Questionnaire Depression Scale (PHQ-9). Spearman correlation analysis was used to determine the correlation among the scales. Then the mediation model was constructed using Smart PLS 4.0, and tested with partial least squares algorithm and Bootstrap techniques.Results 332 patients (30.05%) with community schizophrenia were found to have insomnia. AIS scores in patients with schizophrenia were positively correlated with the scores on SLEs, PSQ and PHQ-9 (r=0.165, 0.322, 0.554, P<0.01). Stressful life events indirectly contributed to insomnia through both separate mediation path and chained mediation path of psychotic symptoms and depressive disorder, and the indirect effect size of 0.102, 0.372 and 0.190 was obtained, accounting for 10.46%, 38.15% and 19.49%, respectively.Conclusion The stressful life events not only directly exert an impact on insomnia, but also indirectly contribute to insomnia through both the separate and chained mediation effect of psychotic symptoms and depressive disorder.
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