| 邹茜,汤妮,刘欢慧,张晗婧,马晓洁.精神障碍可能引起高胆固醇血症：一项孟德尔随机化分析[J].四川精神卫生杂志,2025,(2):123-130.Zou Qian,Tang Ni,Liu Huanhui,Zhang Hanjing,Ma Xiaojie,Causal relationship between mental disorders and hypercholesterolemia： a Mendelian randomization analysis[J].SICHUAN MENTAL HEALTH,2025,(2):123-130 |
| 精神障碍可能引起高胆固醇血症：一项孟德尔随机化分析 |
| Causal relationship between mental disorders and hypercholesterolemia： a Mendelian randomization analysis |
| 投稿时间：2024-07-23 |
| DOI：10.11886/scjsws20240723003 |
| 中文关键词: 精神障碍 高胆固醇血症 孟德尔随机化 代谢综合征 |
| 英文关键词:Mental disorders Hypercholesterolemia Mendelian randomization Metabolic syndrome |
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| 中文摘要: |
| 背景 精神障碍患者易出现代谢综合征（MetS），包括舒张压或收缩压升高、空腹血糖水平升高、高胆固醇血症以及腹型肥胖等。高胆固醇血症作为MetS的重要组成部分，其与精神疾病之间的关系已有报道，但关于精神障碍本身是否会引起高胆固醇血症，目前尚缺乏全基因组关联研究（GWAS）的支持。目的 通过双样本孟德尔随机化（MR）分析方法，探究精神障碍与高胆固醇血症之间的潜在因果关系。方法 对GWAS的汇总数据进行分析，使用与暴露因素（精神障碍）密切相关的单核苷酸多态性（SNP）作为工具变量，以高胆固醇血症为结局变量。分别采用逆方差加权（IVW）法、MR-Egger法和加权中位数（WME）法进行因果分析，以简单众数（SM）法和加权众数（WM）法对结果进行补充，以优势比（OR）评估精神障碍与高胆固醇血症的因果关系。结果 共纳入36个与精神障碍相关的SNP作为工具变量。以IVW法的结果为主要结论，结果显示，精神障碍与高胆固醇血症之间存在因果关系（IVW：OR=1.067，95% CI：1.026~1.109，P=0.001）。其余方法（MR-Egger法、WME法、SM法、WM法）的结果与IVW法的结果基本一致。进一步验证此结论，未发现精神障碍与高胆固醇血症之间的因果关系受遗传多态性的影响（P>0.05）。应用Cochran’s Q检验和MR-Egger法对IVW法中的异质性进行计算，无统计学异质性（P>0.05）。进一步进行反向因果关联的验证，无明显证据支持高胆固醇血症可引起精神障碍（P>0.05）。结论 精神障碍与高胆固醇血症之间存在因果关系，精神障碍患者罹患高胆固醇血症的风险可能增加。 |
| 英文摘要: |
| Background Metabolic syndrome （MetS） is highly prevalent in patients with mental disorders， including elevated diastolic or systolic blood pressure， elevated fasting glucose， hypercholesterolemia， abdominal obesity and so on. As an important component of MetS， the relationship between hypercholesterolemia and mental disorder has been extensively reported， whereas few genome-wide association studies （GWAS） have been conducted to identify the causal role of mental disorders in hypercholesterolemia.Objective To explore the potential causal relationship between mental disorders and hypercholesterolemia by two-sample Mendelian randomization （MR） method.Methods Summary data from GWAS were analyzed. Single nucleotide polymorphisms （SNPs） strongly associated with mental disorders were chosen as instrumental variables， and hypercholesterolemia was used as outcome variable. MR analysis utilized inverse-variance weighted （IVW）， MR-Egger regression and weighted median estimation （WME） as the primary analytical tool， and supplemented by simple mode （SM） and weighted mode （WM）. The causal relationship between mental disorders and the risk of hypercholesterolemia was illustrated in terms of odds ratio （OR）.Results A total of 36 SNPs associated with mental disorders were identified as instrumental variables. The primary findings from IVW revealed existence of a causal relationship between mental disorders and hypercholesterolemia （IVW： OR=1.067， 95% CI： 1.026~1.109， P=0.001）. Findings from the additional methods （MR-Egger regression， WME， SM， WM） were basically consistent with those reported in IVW method. Further verification indicated that the causal relationship between mental disorders and the risk of hypercholesterolemia was not affected by genetic polymorphism （P>0.05）. The absence of heterogeneity was confirmed through Cochran's Q test and MR-Egger regression （P>0.05）. Furthermore， no causal association in the reverse direction was found （P>0.05）.Conclusion There is a causal relationship between mental disorders and hypercholesterolemia， and patients with mental disorders may have an increased probability of suffering from hypercholesterolemia. |
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