| 罗才润,米虹燕,杨英,李佳琦,杨晓斌.音乐辅助药物治疗对中重度老年痴呆患者精神行为症状及认知功能的影响[J].四川精神卫生杂志,2025,(3):235-240.Luo Cairun,Mi Hongyan,Yang Ying,Li Jiaqi,Yang Xiaobin,Effects of music assisted drug treatment on behavioral and psychological symptoms and cognitive function in the elderly with moderate to severe dementia[J].SICHUAN MENTAL HEALTH,2025,(3):235-240 |
| 音乐辅助药物治疗对中重度老年痴呆患者精神行为症状及认知功能的影响 |
| Effects of music assisted drug treatment on behavioral and psychological symptoms and cognitive function in the elderly with moderate to severe dementia |
| 投稿时间：2024-04-18 |
| DOI：10.11886/scjsws20240418001 |
| 中文关键词: 音乐辅助药物治疗 痴呆 精神行为症状 认知功能 |
| 英文关键词:Music assisted drug intervention Dementia Behavioral and psychological symptoms Cognitive function |
| 基金项目:德阳市哲学社会科学研究“十四五”规划2023年度项目（项目名称：集体音乐干预对老年痴呆患者焦虑症状的影响，项目编号：DY232C002） |
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| 中文摘要: |
| 背景 随着我国老龄化进程的加快，老年痴呆的患病率逐年增加。精神行为症状和认知功能受损严重影响老年痴呆患者的生活质量，而药物治疗具有一定局限性，音乐辅助药物治疗可能有助于改善老年痴呆患者的精神行为症状及认知功能，但针对中重度老年痴呆患者的研究有限。目的 探讨音乐辅助药物治疗对中重度老年痴呆患者精神行为症状和认知功能的影响，以期为改善中重度老年痴呆患者精神行为症状和认知功能提供参考。方法 采用随机对照研究，连续选取2023年1月—7月于德阳市精神卫生中心老年精神科住院治疗的、符合《国际疾病分类（第10版）》（ICD-10）痴呆诊断标准的43例伴有精神行为症状的中重度老年痴呆患者，使用SPSS 26.0生成随机数将患者分为研究组（n=22）和对照组（n=21）。两组均接受常规药物治疗及护理，研究组在此基础上接受为期8周、每周2次、每次30 min的音乐辅助治疗。于干预前后，采用神经精神症状问卷（NPI）和简易精神状态评价量表（MMSE）进行评定。结果 共36例患者完成本研究，其中研究组20例、对照组16例。干预前，两组NPI和MMSE总评分比较，差异均无统计学意义（P均>0.05）。干预后，研究组NPI总评分低于干预前，差异有统计学意义［58.00（49.00，79.25） vs. 78.50（55.00，95.50），Z=-3.902，P<0.01］，MMSE总评分与干预前比较，差异无统计学意义（P>0.05）。干预后，研究组NPI总评分、激越/攻击评分、抑郁/心境恶劣评分、焦虑评分、异常运动行为评分均低于对照组，差异均有统计学意义（Z=-2.183、-2.438、-2.691、-3.716、-2.250，P<0.05或0.01）；两组MMSE总评分比较，差异无统计学意义（P>0.05）。结论 音乐辅助药物治疗可能有助于改善中重度老年痴呆患者的精神行为症状，但对患者的认知功能无明显改善作用。 |
| 英文摘要: |
| Background With the acceleration of population aging in China， studies have documented an increased prevalence of dementia in the elderly. Behavioral and psychological symptoms and impaired cognitive function are important problems affecting the quality of life in the elderly with dementia. It has been noted that there are certain limitations on the management of problems mentioned above by drug treatment alone， while its combination with music intervention is emerging as an effective approach. However， the application of this approach in the elderly with moderate to severe dementia is still in its relative infancy.Objective To investigate the effect of music assisted drug treatment on behavioral and psychological symptoms and cognitive function in the elderly with moderate to severe dementia， so as to provide insights for the development of effective intervention.Methods A randomized controlled study was utilized to enroll a coherent of 43 elderly patients with moderate to severe dementia who were hospitalized in Geriatric Psychiatry of Deyang Mental Health Center from January to July 2023 and met the International Classification of Diseases， tenth edition （ICD-10） diagnostic criteria for dementia. Eligible subjects were divided into study group （n=22） and control group （n=21） based on random allocation using SPSS 26.0. Both groups received routine drug treatment and nursing care， while the study group added music intervention， which consisted of two 30-minute sessions per week for 8 weeks. Neuro Psychiatric Inventory （NPI） and Mini-Mental State Examination （MMSE） were administered to all patients before and after intervention.Results A total of 36 patients completed the study， including 20 case in study group and 16 case in control group. No statistical difference was noted in baseline NPI score and MMSE score between two groups （P>0.05）. After intervention， study group reported a statistical reduction in NPI total score ［58.00 （49.00， 79.25） vs. 78.50 （55.00， 95.50）， Z=-3.902， P<0.01）］ along with a clinically unremarkable increase in MMSE score （P>0.05） compared with baseline data. After intervention， NPI total score and scores on sub-domains including agitation/aggression， depression/dysphoria， anxiety and aberrant motor behavior were all significantly lower in study group than those in control group （Z=-2.183， -2.438， -2.691， -3.716， -2.250， P<0.05 or 0.01）， while there was no significant difference in MMSE score between two groups （P>0.05）.Conclusion Music assisted drugintervention may ameliorate behavioral and psychological symptoms in the elderly with moderate to severe dementia， while no significant improvement is documented on cognitive function. ［Fund by the "14th Five Year Plan" for Philosophy and Social Sciences Research in Deyang （number， DY232C002）］ |
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