| 王颖,侯宇威,张哲.中国人群抑郁症疾病负担的年龄-时期-队列分析[J].四川精神卫生杂志,2025,(3):254-260.Wang Ying,Hou Yuwei,Zhang Zhe,Age-period-cohort analysis of disease burden of depressive disorders in the Chinese population[J].SICHUAN MENTAL HEALTH,2025,(3):254-260 |
| 中国人群抑郁症疾病负担的年龄-时期-队列分析 |
| Age-period-cohort analysis of disease burden of depressive disorders in the Chinese population |
| 投稿时间：2024-07-20 |
| DOI：10.11886/scjsws20240720001 |
| 中文关键词: 抑郁症 疾病负担 年龄-时期-队列模型 |
| 英文关键词:Depressive disorders Disease burden Age-period-cohort model |
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| 中文摘要: |
| 背景 随着社会压力不断增加，精神健康问题愈发凸显。抑郁症是一种慢性复发性精神障碍，不仅影响患者的身心健康，还会带来巨大的经济负担。既往针对中国抑郁症患者的研究多为横断面调查，虽能反映特定时点的患病率，但缺乏从年龄、时期、队列多维度的系统剖析。目的 分析1990年—2021年中国人群抑郁症疾病负担的长期变化趋势，为抑郁症的防治提供参考。方法 通过2021年全球疾病负担数据库（GBD 2021）获取中国人群抑郁症疾病负担的相关数据。采用联结点回归模型分析中国人群抑郁症疾病负担的变化趋势，采用Stata 17.0构建年龄-时期-队列模型，分析抑郁症发病率以及疾病负担在年龄、时期以及队列因素影响下的变化。结果 1990年—2021年，中国人群伤残调整寿命年（DALY）率平均每年下降0.27%，中国人群抑郁症发病率平均每年下降0.24%，女性抑郁症发病率和DALY率均高于男性。年龄-时期-队列模型分析结果显示，中国人群抑郁症发病和疾病负担的年龄效应系数整体呈升高趋势，时期效应系数呈下降趋势，队列效应系数的变化呈先升高、后降低趋势。结论 1990年—2021年，中国人群抑郁症发病率和DALY率总体呈下降趋势，女性抑郁症发病和DALY风险均高于男性，且抑郁症发病率和DALY风险随年龄的增加逐渐升高，随时期推移逐渐下降。 |
| 英文摘要: |
| Background Mental health issues have become increasingly prominent amid rising societal pressure. Depressive disorders， characterized as chronic and recurrent conditions， adversely affect patients' physical and mental well-being while imposing a significant economic burden. Previous studies on depressive disorders in China have relied on cross-sectional surveys， capturing prevalence at specific time points， but lacking systematic analyses across age， period， and cohort dimensions.Objective To analyze long-term trends in the disease burden of depressive disorder in the Chinese population from 1990 to 2021， and to provide references to inform prevention and treatment strategies.Methods Data on the disease burden of depressive disorders in China were obtained from the Global Burden of Disease Study 2021 （GBD 2021） database. A joinpoint regression model was used to analyze trends in the disease burden. An age-period-cohort model， implemented in Stata 17.0， was applied to assess variations in incidence and disease burden attributable to age， period and cohort effects.Results From 1990 to 2021， the disability-adjusted life year （DALY） rate for depressive disorders in China decreased by an average of 0.27% annually， while the incidence rate decreased by an average of 0.24% annually. Females had higher incidence and DALY rates than those of males. The age-period-cohort model analysis revealed that age effects on incidence and disease burden steadily increased， period effects declined over time， and cohort effects initially increased and then declined.Conclusion From 1990 to 2021， both the incidence and DALY rates of depressive disorders in China showed a declining trend. Females experienced a higher burden compare to males. Additionally， incidence and DALY rates increased with age but declined over time. |
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