| Objective To investigate the distribution of disease spectrum of children and adolescents in the inpatient department of the Children's Mental Health Research Center of Nanjing Brain Hospital and drug choice in the final clinical treatment plan. Methods From March 2012 to July 2019, the diagnosis and classification of children and adolescents who were hospitalized in the inpatient department of children's mental health research center of Nanjing Brain Hospital at the time of discharge and the types and doses of drugs taken at the time of discharge were analyzed retrospectively. Results 1) A total of 2153 patients were included, and the most common diseases were schizophrenia and related spectrum disorders (40.8%), neurodevelopmental disorders and associated disorders (17.4%), and depressive disorders (16.6%) . 2）There were 2098 patients (98.3%) having psychotropic drugs in their prescriptions among all patients, in which the top five prescriptions of psychotropic drugs, in turn, were aripiprazole (31.7%), sertraline (26.7%), olanzapine (19.1%), risperidone (16.5%) and sodium valproate (12.0%). 3) The analysis of the trend of drug use in different years found that the usage frequency of antipsychotic drugs in the past three years was lower than that of the previous four years (P<0.05); and there was no statistically significant difference in the usage frequency of other drugs in different years (P > 0.05). 4) Aripiprazole and risperidone were used more frequently in the children group than that in the adolescent group (P < 0.05); and the usage frequency of olanzapine, paliperidone and quetiapine in the adolescent group was higher than that in the children group (P < 0.05). Compared with female children patients, risperidone was used more frequently by male patients(P<0.05), and aripiprazole and quetiapine were less used. (P<0.05). Conclusion The drug use of hospitalized children and adolescents with mental diseases changes over time, and the types of prescription drugs are closely related to the disease type, age, gender and times. |