|
| 首发精神病快感缺失水平与认知功能的关系 |
| The correlation of anhedonia and cognitive function for first episode psychosis |
| 投稿时间：2021-02-26 修订日期：2021-06-07 |
| DOI： |
| 中文关键词: 首发精神病 认知功能 快感缺失 阴性症状 |
| 英文关键词:First episode psychosis Cognitive function Anhedonia Negative symptom |
| 基金项目:国家重点基础研究发展计划（973计划） |
|
| 摘要点击次数: |
| 全文下载次数: |
| 中文摘要: |
| 目的 探讨首发精神病患者快感缺失水平及其与认知功能的关系，分析首发精神病患者认知功能的影响因素 。方法 选取2016年12月-2019年3月在广州医科大学附属脑科医院就诊的符合DSM-5诊断标准的首发精神病患者143例。采用阳性和阴性症状评定量表（PANSS）来评价患者的精神症状，其中N2情绪退缩+N4被动/淡漠社交退缩评价患者的快感缺失水平，（N2+N4）分数>4分定义为快感缺失组，（N2+N4）分数≤4分定义为无快感缺失组；采用汉密尔顿抑郁量表24项（HAMD-24）及精神分裂症认知功能成套测验（MCCB）来评价情绪症状和认知功能。采用独立样本t检验比较快感缺失组和无快感缺失组间症状学及认知功能差异，采用多元线性回归分析探讨认知功能的影响因素。结果 快感缺失组的阴性症状分、一般病理症状分及PANSS总评分高于无快感缺失组，差异有统计学意义（P<0.05）；青少年亚组快感缺失组的工作记忆、成年快感缺失组患者的信息处理速度、注意/警觉性、词语学习均高于无快感缺失组（P均<0.05）。多元线性回归分析结果显示，青少年亚组快感缺失评分及未治疗期是工作记忆的影响因素（P<0.05）。结论 快感缺失水平高的患者精神症状更严重，快感缺失是工作记忆的影响因素之一。 |
| 英文摘要: |
| Objective To explore the level of anhedonia in patients with first episode psychosis and its relationship with cognitive function,and analyze the influencing factors of cognitive function in patients with first-episode psychosis.. Methods A total of 143 first-episode psychiatric patients who met the DSM-5 diagnostic criteria at the the Affiliated Brain Hospital of Guangzhou Medical University from December 2016 to March 2019 were selected. The Positive and Negative Symptom Scale (PANSS) was used to evaluate the patient’s psychiatric symptoms, in which N2 emotional withdrawal + N4 Passive/apathetic social withdrawal was used to evaluate the patient’s anhedonia level; and patients whose (N2+N4) scores> 4 were defined as anhedonia group , whose (N2+N4) score ≤ 4 points were defined as no anhedonia group. The Hamilton Depression Scale 24 (HAMD-24) were used to evaluate emotional symptoms, and the Matrics Consensus Cognitive Battery (MCCB) was used to evaluate Cognitive function. The independent sample t test was used to compare the differences in symptoms and cognitive function between the two groups, and the multiple linear regression analysis was used to explore the influencing factors of cognitive function. Results The negative symptom score, general pathological symptom score and total PANSS score of the anhedonia group were higher than those of the no anhedonia group, and the difference was statistically significant (P<0.05). the working memory of the anhedonia group in the adolescent subgroup were higher than those in the nonhedonia group, so as the information processing speed, attention/alertness, and vocabulary learning in the adult subgroup(all P<0.05) . The results of multiple linear regression analysis showed that the anhedonia score and untreated duration of psychosis of adolescent subgroups were the influencing factors of working memory (P<0.05). Conclusion Patients with high levels of anhedonia have more severe mental symptoms, and anhedonia is one of the influencing factors of working memory. |
| 查看/发表评论 下载PDF阅读器 |
| 关闭 |