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| 首发精神分裂症患者快感缺乏的成分特征与相关因素 |
| Analysis of the component factors and connected factors of anhedonia in patients with first-episode schizophrenia |
| 投稿时间：2021-04-29 修订日期：2021-06-07 |
| DOI： |
| 中文关键词: 精神分裂症 快感缺乏 时间性愉快体验量表 |
| 英文关键词:Schizophrenia Anhedonia Temporal Experiences of Pleasure Scale |
| 基金项目:广州市卫生健康科技一般引导项目（项目名称：精神分裂症情绪信息视听整合障碍与社交退缩相关性的神经电生理研究) |
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| 中文摘要: |
| 目的 探索首发精神分裂症患者快感缺乏的成分特征及其与临床症状、认知功能和社会功能的相关性。方法 纳入符合《国际疾病分类（第10版）》（ICD-10）诊断标准的31例首发精神分裂症患者和33例健康对照组。使用愉快情绪体验量表（TEPS）、阳性和阴性症状量表（PANSS）评估、重复性成套神经心理状态测验（RBANS）以及个人和社会功能量表（PSP）对患者的快感缺乏情况、精神症状、认知功能和社会功能进行评定。采用Pearson相关分析快感缺乏与临床症状、认知功能和社会功能的相关性。结果 精神分裂症患者TEPS快感评分低于健康对照组，差异有统计学意义[（27.71±5.48）分vs.（31.58±5.92）分，t=2.705，P=0.009]。相关分析显示，首发精神分裂症患者消费性快感缺乏与PANSS、RBANS和PSP评分的相关均无统计学意义（P均>0.05）。结论 首发精神分裂症患者存在消费性快感缺乏而非期待性快感缺乏。首发精神分裂症患者的消费性快感缺乏可能独立于临床症状、认知功能损害和社会功能损害之外。 |
| 英文摘要: |
| Objective To explore the characteristics of different factors of anhedonia in first-episode schizophrenia (SZ) and its correlation with clinical symptoms, cognitive functioning and social functioning. Methods A total of 31 patients with first-episode schizophrenia who met the diagnostic criteria of the International Classification of Diseases (10th Revision) (ICD-10) ,and 33 healthy controls were enrolled. Temporal Experiences of Pleasure Scale (TEPS) and Repetitive Battery of Neuropsychological Status (RBANS) were applied to assess anhedonia and cognitive function for each participants. The Positive and Negative Symptom Scale (PANSS) for symptoms and the Personal and Social Functioning Scale (PSP) for social cognitive functioning were administered to the patients. Pearson correlation was used to evaluate the correlation between anhedonia and clinical symptoms, cognitive functioning and social functioning. Results The patient group had a statistically significant lower TEPS consummatory pleasure scores than healthy controls[（27.71±5.48）vs.（31.58±5.92）, t=2.705, P=0.009]. The consummatory pleasure scores was not linearly correlated with PANSS, RBANS, or PSP scores in the patient group (P>0.05). Conclusion Patients with first-episode schizophrenia exhibit consumer anhedonia but not anticipatory anhedonia. Consumer anhedonia in patients with first-episode schizophrenia may be lack of correlation with clinical symptoms, cognitive functioning or social functioning. |
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