青少年情感障碍的睡眠结构特征与自杀风险的相关性研究
Correlation between sleep structure characteristics and suicide risk in adolescents with affective disorder
投稿时间:2022-02-18  修订日期:2022-09-15
DOI:
中文关键词:  青少年  抑郁障碍  双相情感障碍  多导睡眠监测  自杀风险
英文关键词:Teenagers  Depressive disorder  Bipolar disorder  Polysomnography  Suicide risk
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作者单位地址
项心明 广州医科大学附属脑科医院 广东省广州市荔湾区明心路广州医科大学附属脑科医院
何红波 广州医科大学附属脑科医院 广东省广州市荔湾区明心路广州医科大学附属脑科医院
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中文摘要:
      【摘要】目的 通过分析青少年抑郁障碍和双相情感障碍住院患者的睡眠结构特征的差异及其与自杀的相关性,探讨青少年情感障碍患者自杀的潜在高危因素。方法 本研究回顾性查阅广州医科大学附属脑科医院病历资料中2019年1月1日至2021年6月30号住院青少年患者(12-20岁),收集患者的年龄、性别、精神科诊断、自杀风险评估量表(NGASR)评分、多导睡眠监测仪(PSG)监测的睡眠参数等资料。纳入有完整PSG、NGASR评估数据全部患者,根据收集到的资料和监测结果采用 SPSS25.0 进行相关统计分析。结果 共149例住院患者纳入分析,其中抑郁97例,双相52例。相比既往文献报道的正常青少年,抑郁和双相患者的快速眼球运动期占比(RT%)均显著降低,抑郁患者较双相患者的睡眠总时间(TST)、睡眠效率(SE)明显减少。根据NGASR评分,将所有患者分为低风险组(n=97)和高风险组(n=52),高风险组较低风险组睡眠效率降低。多元线性回归分析发现,青少年情感障碍自杀风险的影响因素包括非快速眼球运动1期时间(S1)(β=0.019)、性别(男性vs女性,β=-4.051)、诊断(双相情感障碍vs抑郁障碍,β=-1.429)。结论 本研究结果分析表明,青少年抑郁和双相情感障碍患者相比正常青少年的睡眠指标存在明显差异。S1、女性、抑郁障碍为青少年自杀风险的危险因素。青少年睡眠指标与自杀风险之间的关系有必要进一步深入研究。
英文摘要:
      【Abstract】Objective By analyzing the differences of sleep structure characteristics between hospitalized patients with adolescent depression and bipolar disorder and their correlation with suicide, this paper discusses the potential high-risk factors of suicide in patients with adolescent affective disorder. Methods This study retrospectively reviewed the medical records of adolescent patients (12-20 years old) hospitalized from January 1, 2019 to June 30, 2021 in the Affiliated Brain Hospital of GUANGZHOU Medical University, and collected the age, gender, psychiatric diagnosis, NGASR score, sleep parameters monitored by polysomnography (PSG) and other data. All patients with complete PSG and NGASR evaluation data were included. According to the collected data and monitoring results, SPSS25.0 was used to relevant statistical analysis. Results A total of 149 inpatients were included in the analysis, including 97 cases of depression and 52 cases of bipolar disorder. Compared with the normal teenagers for previous literature, the proportion of rapid eye movement (RT%) in patients with depression and bipolar disorder was significantly lower, and the total sleep time (TST) and sleep efficiency (SE) of patients with depression were significantly lower than those of patients with bipolar disorder. According to the NGASR score, all patients were divided into low-risk group (n = 97) and high-risk group (n = 52). The sleep efficiency of high-risk group was lower than that of low-risk group. Multiple linear regression analysis showed that the influencing factors of adolescent affective disorder suicide risk included non rapid eye movement stage 1(β= 0.019), gender (male vs female, β=- 4.051) diagnosis (bipolar disorder vs depressive disorder, β=- 1.429)。Conclusion The analysis of the results of this study shows that there are significant differences in sleep indicators between adolescents with depression and bipolar disorder compared with normal adolescents. The risk factors of S1 and depression were female. The relationship between sleep indicators and suicide risk in adolescents needs to be further studied.
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