| 【Abstract】Objective By analyzing the differences of sleep structure characteristics between hospitalized patients with adolescent depression and bipolar disorder and their correlation with suicide, this paper discusses the potential high-risk factors of suicide in patients with adolescent affective disorder. Methods This study retrospectively reviewed the medical records of adolescent patients (12-20 years old) hospitalized from January 1, 2019 to June 30, 2021 in the Affiliated Brain Hospital of GUANGZHOU Medical University, and collected the age, gender, psychiatric diagnosis, NGASR score, sleep parameters monitored by polysomnography (PSG) and other data. All patients with complete PSG and NGASR evaluation data were included. According to the collected data and monitoring results, SPSS25.0 was used to relevant statistical analysis. Results A total of 149 inpatients were included in the analysis, including 97 cases of depression and 52 cases of bipolar disorder. Compared with the normal teenagers for previous literature, the proportion of rapid eye movement (RT%) in patients with depression and bipolar disorder was significantly lower, and the total sleep time (TST) and sleep efficiency (SE) of patients with depression were significantly lower than those of patients with bipolar disorder. According to the NGASR score, all patients were divided into low-risk group (n = 97) and high-risk group (n = 52). The sleep efficiency of high-risk group was lower than that of low-risk group. Multiple linear regression analysis showed that the influencing factors of adolescent affective disorder suicide risk included non rapid eye movement stage 1（β= 0.019), gender (male vs female, β=- 4.051) diagnosis (bipolar disorder vs depressive disorder, β=- 1.429）。Conclusion The analysis of the results of this study shows that there are significant differences in sleep indicators between adolescents with depression and bipolar disorder compared with normal adolescents. The risk factors of S1 and depression were female. The relationship between sleep indicators and suicide risk in adolescents needs to be further studied.