| Objective To understand the detection rate and related factors of depression and anxiety of disabled people in post-epidemic period, and to provide reference for promoting mental health of disabled people. Methods From April to May 2021, a voluntary sampling method was used in this study. Through the questionnaire star network platform, the disabled people in Guang ' an City who?lived in low-risk areas during the first half year before investigation and comply?with?the?national?standards?for?the?classification?and?classification?of?disabled?persons（GB/T26341-2010）were investigated. The incidence of depression and anxiety symptoms of the disabled was evaluated by the Patients’ Health Questionnaire Depression Scale-9 item (PHQ-9) and the Generalized Anxiety Disorder (GAD-7). The risk and protective factors of depression and anxiety of the disabled were analyzed by binary Logistic regression. Results The detection rates of moderate and severe depressive symptoms were 9.05 % and 8.35 %, and the detection rates of moderate and severe anxiety symptoms were 9.40% and 11.25%. The results of regression analysis showed that unemployment or unemployment were risk factors for depression and anxiety of disabled people (OR=2.354, 2.353, P<0.01). Unmarried(OR=0.418), married(OR=0.414), visual disability(OR=0.254), limb disability(OR=0.460), good family function(OR=0.241), moderate family dysfunction(OR=0.288), complete self-care(OR=0.062) and partial self-care(OR=0.416) were protective factors for depression in persons with disabilities(P<0.05 or 0.01); visual disability(OR=0.382), hearing disability(OR=0.143), limb disability(OR=0.432), good family function(OR=0.246), moderate family dysfunction(OR=0.402), complete self-care(OR=0.093) and partial self-care(OR=0.378) were protective factors for anxiety of disabled people(P<0.05 or 0.01). Conclusion The detection rate of depression and anxiety of the disabled in Guang ’ an City is still high during the post-epidemic period. The disabled who are unemployed or unemployed have a higher risk of depression and anxiety symptoms, while good family function and complete or partial self-care ability are conducive to protecting the mental health of the disabled.