事件相关电位P300在颅脑损伤后认知功能障碍中的应用
Application of event-related potential P300 in cognitive dysfunction after traumatic brain injury
投稿时间:2022-04-01  修订日期:2022-06-16
DOI:
中文关键词:  颅脑损伤  事件相关电位  P300  认知功能障碍
英文关键词:traumatic brain injury  event-related potential  P300  cognitive dysfunction
基金项目:四川应用心理学研究中心项目(CSXL-212B03)
作者单位地址
钟俊 绵阳市第三人民医院/四川省精神卫生中心 神经外科 四川省绵阳市游仙区剑南路东段190号
刘阳 绵阳市第三人民医院/四川省精神卫生中心 神经外科 四川省绵阳市游仙区剑南路东段190号
徐剑峰 绵阳市第三人民医院/四川省精神卫生中心 神经外科 
张海 绵阳市第三人民医院/四川省精神卫生中心 神经外科 
廖帅 绵阳市第三人民医院/四川省精神卫生中心 神经外科 
文汧卉 绵阳市第三人民医院/四川省精神卫生中心 神经外科 
王雪 绵阳市第三人民医院/四川省精神卫生中心 神经外科 
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中文摘要:
      目的 探讨事件相关电位P300在颅脑损伤后认知功能障碍中的应用价值。方法 选取2021年1月-9月在绵阳市第三人民医院神经外科保守治疗的、符合诊断标准的颅脑损伤患者36例作为研究组,同期在医院其他患者家属和护工中招募正常对照组36名,均采用Oddball范式进行事件相关电位P300检测,同时,使用蒙特利尔认知评估量表(MoCA)和简易精神状态评价量表(MMSE)评估受试者的认知功能,比较两组受试者P300的潜伏期和波幅以及MoCA和MMSE评分。比较P300潜伏期、MoCA和MMSE对认知功能障碍的检出率。结果 研究组MoCA、MMSE评分均低于对照组[(18.08±4.23)分vs.(27.36±1.18)分,(22.53±3.49)分vs.(28.11±1.07)分,t=-12.510、-9.041,P均<0.05];研究组P300潜伏期高于对照组[(406.08±26.57)ms vs.(367.08±22.18)ms,t=6.665,P<0.05],波幅低于对照组[(7.76±0.88)uv vs.(9.87±0.97)uv,t=-9.469,P<0.05]。研究组P300潜伏期、MoCA的检出率高于研究组MMSE的检出率(χ2=5.675、7.604,P均<0.05)。结论 P300可以作为评估颅脑损伤后认知功能障碍的一种客观的临床指标,P300潜伏期、MoCA在筛查中较MMSE敏感,P300在临床中具有一定的应用价值。
英文摘要:
      Objective To explore the application value of event-related potential P300 in cognitive dysfunction after traumatic brain injury. Methods From January to September 2021, a total of 36 patients with traumatic brain injury who were conservatively treated in the Neurosurgery Department of the Third Hospital of Mianyang and met the diagnostic criteria were selected as the research group, and 36 normal control groups were recruited from the family members and nurses of other patients in the hospital during the same period. Oddball paradigm was used to measure the event-related potential P300. Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) were used to assess the cognitive function of the subjects. P300 latency and amplitude, MoCA and MMSE scores were compared between the two groups, and the detection rates of P300 latency, MoCA and MMSE on cognitive dysfunction in patients with traumatic brain injury were compared. Results MoCA and MMSE scores in the study group were lower than those in the control group [(18.08±4.23) vs. (27.36±1.18), (22.53±3.49) vs. (28.11±1.07), t=-12.510, -9.041, P<0.05]. The latency of P300 in the study group was higher than that in the control group [(406.08±26.57)ms vs. (367.08±22.18)ms, t=6.665, P<0.05], and the amplitude was lower than that in the control group [(7.76±0.88)μV vs. (9.87±0.97)μV, t=-9.469, P<0.05]. In study group, the positive rate of P300 latency and the rate of MoCA on cognitive dysfunction were higher than that in MMSE (χ2=5.675, 7.604, P<0.05). Conclusion P300 can be used as an objective clinical indicator for evaluating cognitive dysfunction in patients with traumatic brain injury.
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