| 王静.喹硫平、氯氮平联合碳酸锂治疗女性躁狂症的随机对照研究[J].四川精神卫生杂志,2014,27(1):60-62.WANG Jing,Randomized controlled clinical research of quetiapine or clozapine combined with lithium carbonate in the treatment of mania in women[J].SICHUAN MENTAL HEALTH,2014,27(1):60-62 |
| 喹硫平、氯氮平联合碳酸锂治疗女性躁狂症的随机对照研究 |
| Randomized controlled clinical research of quetiapine or clozapine combined with lithium carbonate in the treatment of mania in women |
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| 中文关键词: 喹硫平 氯氮平 碳酸锂 躁狂症 |
| 英文关键词:Quetiapine Clozapine Lithium carbonate Mania disorder |
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| 中文摘要: |
| 目的 探讨使用喹硫平或氯氮平合并碳酸锂治疗女性躁狂发作的临床疗效.方法 将符合《国际疾病分类（第10版）》（ICD-10）情感障碍中“躁狂发作”或“双相障碍目前为躁狂发作”诊断标准的64例女性躁狂症患者采用分段随机分组法分为两组,分别予喹硫平和氯氮平联合碳酸锂治疗6周.采用Bech-Rafaelsen躁狂量表（BRMS）评价药物的总体有效性,采用副反应量表（TESS）和血、尿常规、生化、心电图、脑电图检查评价安全性及不良反应,并用成本-效果分析计算药物的经济性.结果 两组有效率比较差异无统计学意义（P＞0.05）,但两组在不良反应头晕、嗜睡、心电图、便秘、流涎、血糖异常、体质量增加等方面比较差异有统计学意义（P＜0.05）,喹硫平组副反应率低于氯氮平组,差异有统计学意义（P＜0.05）.结论 两药物组的临床疗效相当,但喹硫平组副反应率低于氯氮平组.喹硫平合并碳酸锂可能更适用于治疗女性躁狂发作. |
| 英文摘要: |
| Objective To explore the clinical efficacy of lithium carbonate combined with quetiapine and clozapine in the treat- ment of mania in women. Methods 64 female mania disorder patients were randomly divided into two groups. They took quetiapine or clozapine combined with lithium carbonate for both 6 weeks treatment. The BRMS were adopted to test the clinical efficacy while the TESS and lab tests were administered to evaluate side effects. Results There were no significant difference in the clinical efficacy （P 〉 0.05 ）, while significantly differences in anticholinergie effect,weight gain between two groups （ P 〈 0.05 ）. Conclusion The results indicate the clinical effectiveness of the two drug groups were similar, while different in side effects. Lithium carbonate combined with quetiapine to maybe more suitable for mania disorder in women |
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