| 潘能荣,李哲,黄自勇.难治性抑郁症停药清洗合并MECT一周及后续治疗反应[J].四川精神卫生杂志,2014,27(2):154-156.PAN Neng - rong,LI Ze,HUANG Zhi - yong,The study of treatment response of one week washout with MECT and subsequent treatment on treatment refractory depression[J].SICHUAN MENTAL HEALTH,2014,27(2):154-156 |
| 难治性抑郁症停药清洗合并MECT一周及后续治疗反应 |
| The study of treatment response of one week washout with MECT and subsequent treatment on treatment refractory depression |
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| DOI：10.11886/scjsws201402018 |
| 中文关键词: 无抽搐电休克治疗 难治性抑郁症 清洗 |
| 英文关键词:Modified Electraconvulsive therapy Toyota Racing Development Washout |
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| 中文摘要: |
| 目的 探讨对难治性抑郁症患者，停药清洗1周并同期合并无抽搐电休克治疗（MECT）的效果，并评价1周后续用先前抗抑郁药的治疗反应。方法将符合《中国精神障碍分类与诊断手册（第3版）》（CCMD-3）抑郁症诊断标准的40例难治性抑郁症患者，予1周的清洗，清洗期停用除苯二氮革类药物以外的所有精神科药物，同期合并MECT治疗，清洗期结束后继续使用原抗抑郁药物，共观察6周。在MECT治疗前及治疗后第1、2、4、6周末分别采用汉密尔顿抑郁量表（HAMD-17）、汉密尔顿焦虑量表（HAMA）评定疗效，用副反应量表（TESS）评定不良反应。结果（髓周末痊愈14例，显效17例，进步7例，无效2例。有效率77．5％。②治疗第1周末（清洗期合并MECT后）HAMD-17、HAMA评分较治疗前差异有统计学意义（P均〈0．01）。治疗第4周末（即重新开始续用原抗抑郁药后第3周）和第6周末HAMD-17、HAMA评分与第1周末比较差异均有统计学意义（P〈0．05或0．01）。结论停药清洗1周合并MECT对难治性抑郁症效果良好，经过清洗合并MECT后可提高原抗抑郁药物的疗效 |
| 英文摘要: |
| Objective To evaluate the treatment response of a week washout with MECT and subsequent treatment on treatment refractory depression. Methods 40 patients with treatment refractory depression were discontinued all psychotropic drugs except henzodiazepines and received MECT for a week and subsequent antidepressant drugs combined with MECT treatment for five weeks. The HAMD - 17 ,HAMAand TESS were measured respectively before MECT and after MECT for 1,2,4,6 weeks. Results①After 6 weeks MECT, The symptoms of 14 patients were in remission, 17 patients had treatment response , and the efficiency rate is 77.5%. ②HAMD - 17 and HAMA scores were decreased significantly after a week treatment. There were significant differences in HAMD - 17 and HAMA scores afterl, 4, 6 weeks treatment compared with the baseline, at the same time, the scores at the end of 4 and 6 weeks treatment were significantly decreased than that at the end of 1 week treatment. Conclusion The effect of treatment withdrawal with MECT is good, and subsequent antidepressant drugs combined with MECT treatment can improve the therapeutic efficacy of the antidepressant drugs |
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