| 贺长兴,邹韶红,贾丽娜.酒依赖共病双相情感障碍患者冲动攻击行为与5-HTR1B基因多态性关联分析[J].四川精神卫生杂志,2019,32(1):29-32.,Association between the polymorphism of 5 - hydroxy tryptamineta 1B receptor gene and impulsive aggression behavior in patients with comorbid alcohol dependency and bipolar disorder[J].SICHUAN MENTAL HEALTH,2019,32(1):29-32 |
| 酒依赖共病双相情感障碍患者冲动攻击行为与5-HTR1B基因多态性关联分析 |
| Association between the polymorphism of 5 - hydroxy tryptamineta 1B receptor gene and impulsive aggression behavior in patients with comorbid alcohol dependency and bipolar disorder |
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| DOI：10.11886/j.issn.1007-3256.2019.01.005 |
| 中文关键词: 双相情感障碍 冲动攻击行为 5-羟色胺受体 |
| 英文关键词:Bipolar disorder Impulsive aggression behavior 5 - hydroxy tryptamine receptor |
| 基金项目:新疆维吾尔自治区自然科学基金（2013211A107） |
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| 【摘要】 目的 探讨酒依赖共病双相情感障碍患者的冲动攻击行为与 5 - HTR1B rs6296 基因多态性的关联，为酒依赖共病双相情感障碍患者冲动攻击行为导致病理生理改变机制的潜在遗传学差异的研究提供参考。 方法 采用病例对照研究，纳入符合《精神障碍诊断与统计手册（第 4 版）》(DSM - IV)酒依赖共病双相情感障碍诊断标准的患者 230 例，依据修订版外显攻击行为量表(MOAS)评分分为有冲动攻击行为组(n = 128)和无冲动攻击性行为组(n = 102)。 通过 PCR 直接测序法对rs6296 基因多态性进行测定，并分析 5 - HTR1B rs6296 基因多态性与酒依赖共病双相情感障碍患者冲动攻击行为的关联性。结果 酒依赖共病双相情感障碍患者有冲动攻击行为组与无冲动攻击行为组 rs6296 位点的等位基因频率分布差异无统计学意义(χ2 = 2. 135,P > 0. 05)；两组 rs6296 位点基因型分布差异无统计学意义(χ2 = 2. 771,P > 0. 05)。 结论 酒依赖共病双相情感障碍患者冲动攻击行为与 5 - HTR1B rs6296 基因多态性无关联。 |
| 英文摘要: |
| Objective To investigate the correlation between impulsive aggression behavior and 5 - hydroxy tryptamine 1 B receptor ( 5 - HTR1 B ) gene polymorphisms in patients with comorbid alcohol dependency and bipolar disorder, and to provide references for understanding the potential genetic differences in the mechanism of pathophysiological changes caused by impulsive aggression of patients with comorbid alcohol dependency and bipolar disorder. Methods A total of 230 patients who were diagnosis with alcohol dependency cormobid with bipolar disorder according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition( DSM - IV) were recruited. All patients were divided into the impulsive aggression group ( n = 128 ) and non - impulsive aggressive behavior group ( n = 102) according to the Modified Overt Aggression Scale ( MOAS) score. The polymorphisms of rs6296 were identified by PCR direct sequencing, in addition the relationship between the differences of 5 - HTR1 B rs6296 polymorphisms and impulsive aggression were analyzed. Results There was no significant difference between the genotype of rs6296 in the impulsive aggression group( n = 128) and the non - impulsive aggressive behavior group( χ2 = 2. 135, P > 0. 05) . No significant difference was found between the allele frequency of rs6296 in the two groups ( χ2 = 2. 771 , P > 0. 05) . Conclusion There was no correlation between impulsive aggression behavior and 5 - HTR1B rs6296 polymorphisms in patients with comorbid alcohol dependency and bipolar disorder. |
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