| 陈胡丹,王娟,王新森.阻塞性睡眠呼吸暂停患者临床特征与焦虑抑郁的相关分析[J].四川精神卫生杂志,2019,32(1):33-37.,Correlation between clinical features of obstructive sleep apnea patients and their anxiety and depression symptoms[J].SICHUAN MENTAL HEALTH,2019,32(1):33-37 |
| 阻塞性睡眠呼吸暂停患者临床特征与焦虑抑郁的相关分析 |
| Correlation between clinical features of obstructive sleep apnea patients and their anxiety and depression symptoms |
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| DOI：10.11886/j.issn.1007-3256.2019.01.006 |
| 中文关键词: 阻塞性睡眠呼吸暂停 临床特征 焦虑 抑郁 |
| 英文关键词:Obstructive sleep apnea Clinical features Anxiety Depression |
| 基金项目:四川省医学科研课题项目（S170400) |
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| 中文摘要: |
| 【摘要】 目的 探索阻塞性睡眠呼吸暂停(OSA)患者的临床特征及其与焦虑抑郁症状的关系，为进一步研究两者间具体的发生机制提供参考。 方法 选取 2018 年 3 月 - 9 月在四川省精神卫生中心行多导睡眠监测的患者 238 例，根据呼吸暂停低通气指数(AHI)分为 OSA 组(n = 130)和非 OSA 组(n = 108)。 采用自制一般资料和临床症状调查问卷、Epworth 嗜睡量表(ESS)和匹兹堡睡眠质量指数量表(PSQI)评定患者的临床症状和睡眠质量；采用汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表 24 项版(HAMD - 24)评定患者的焦虑和抑郁症状。 分析 OSA 组临床症状与焦虑抑郁的相关性。 结果 OSA 组打鼾(76. 9% )、夜间憋醒(25. 4% )、认知功能减退(76. 9% )者均比非 OSA 组(分别为 41. 7% ?13. 0% ?63. 9% )多，且 OSA 组症状持续时间更长，差异均有统计学意义(P < 0. 05 或 0. 01)。 OSA 组 ESS?HAMA 和 HAMD - 24 评分均高于非 OSA 组(P 均 < 0. 01)。 相关分析显示，OSA 组临床症状持续时间与 HAMA 评分呈正相关(r = 0. 212,P = 0. 016)；PSQI 评分与 HAMA?HAMD - 24 评分均呈正相关(r = 0. 217?0. 211,P = 0. 014?0. 017)。 结论 OSA 患者常伴有打鼾、夜间憋醒、认知功能减退，且症状持续时间仅与其焦虑水平有关，睡眠质量与焦虑、抑郁的关系均较密切。 |
| 英文摘要: |
| Objective To explore the clinical characteristics of patients with obstructive sleep apnea ( OSA) and their relationship with anxiety and depression symptoms, and to provide references for further study on the specific mechanisms of occurrence among them. Methods A total of 238 patients who got polysomnography at the Sleep Medicine Center of Sichuan Mental Health Center from March 2018 to September 2018 were enrolled. They were divided into the OSA group ( n = 130) and the non - OSA group ( n = 108) according to the apnea hypopnea index ( AHI) . Clinical symptoms and sleep quality were assessed by self - made general information and clinical symptom questionnaire, the Epworth Sleeping Scale ( ESS) and Pittsburgh Sleep Quality Index ( PSQI) . The anxiety and depression condition were assessed by the Hamilton Anxiety Scale ( HAMA) and Hamilton Depression Scale - 24 item( HAMD - 24) . The correlation between clinical symptoms and anxiety and depression of the OSA group were analyzed. Results In the OSA group, snoring ( 76. 9% ) , suppress awake at night ( 25. 4% ) and cognitive impairment ( 76. 9% ) were more common than those in the non - OSA group ( 41 . 7% , 13. 0% , 63. 9% ) , and the duration were longer ( P < 0. 05 or 0. 01 ) . ESS, HAMA and HAMD - 24 scores of the OSA group were significantly higher than those of the non - OSA group ( P < 0. 01 ) . Correlation analysis showed that the duration of clinical symptoms in the OSA group was positively correlated with HAMA score ( r = 0. 212, P = 0. 016) . PSQI score was positively correlated with HAMA and HAMD - 24 scores ( r = 0. 217, 0. 211 , P = 0. 014, 0. 017) . Conclusion Patients with OSA often accompanied with snoring, suppress awake at night and cognitive impairment. The duration of symptoms were only related to the anxiety level, and the sleep quality were related to both anxiety and depression condition. |
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