| 杨俊,佟靓,周立国.首发儿童精神分裂症患者脑源性神经营养因子水平及神经元凋亡研究[J].四川精神卫生杂志,2019,32(2):135-138.,Brain - derived neurotrophic factor level and neuronal apoptosis in first - episode schizophrenia in children[J].SICHUAN MENTAL HEALTH,2019,32(2):135-138 |
| 首发儿童精神分裂症患者脑源性神经营养因子水平及神经元凋亡研究 |
| Brain - derived neurotrophic factor level and neuronal apoptosis in first - episode schizophrenia in children |
| |
| DOI：10.11886/j.issn.1007-3256.2019.02.009 |
| 中文关键词: 脑源性神经营养因子 精神分裂症 儿童 凋亡 神经元 |
| 英文关键词:Brain - derived neurotrophic factor Schizophrenia Children Apoptosis Neurons |
| 基金项目:昆明市卫生和计划育委员会医药卫生科技项目(2018-03-09-004)；昆明市卫生科技人才培养项目暨"十百千"工程(2018-SW(后备人选)-89) |
|
| 摘要点击次数: |
| 全文下载次数: |
| 中文摘要: |
| 【摘要】 目的 探讨首发儿童精神分裂症患者脑源性神经营养因子(BDNF)、β-微管蛋白III(Tuj-1)、胱天蛋白酶3(Caspase-3)的变化,为揭示儿童精神分裂症的病因和发病机制提供参考。方法 以2015年8月-2018年3月在大理州第二人民医院就诊的符合《精神障碍诊断与统计手册(第4版)》(DSM-IV)诊断标准的儿童精神分裂症患者(n=35)为研究组,同期在大理州第二人民医院的体检儿童中随机选取健康儿童为对照组(n=30)。通过实时荧光定量逆转录-聚合酶链反应(RT-PCR)测定两组儿童血液中BDNF、Caspase-3和Tuj-1的mRNA表达水平。结果 与对照组相比,研究组BDNF和Tuj-1 mRNA表达低(P<0.05或0.01),Caspase-3 mRNA表达高(P<0.01)。结论 儿童精神分裂症患者的BDNF mRNA和Tuj-1 mRNA表达少,Caspase-3 mRNA表达多,BDNF mRNA、Tuj-1 mRNA和Caspase-3 mRNA可能与儿童精神分裂症相关。 |
| 英文摘要: |
| Objective To investigate the changes of the brain - derived neurotrophic factor ( BDNF) , class III β - tubulin( Tuj - 1 ) and Caspase - 3 levels in first - episode schizophrenic children, so as to provide references for revealing the etiology and pathogenesis of schizophrenia. Methods 35 cases of schizophrenic children ( study group) met the Diagnostic and Statistical Manual of Mental Disorders, fourth edition ( DSM - IV) and 30 cases of healthy children ( control group) in the Second People's Hospital of Dali Prepecture from August 2015 to March 2018 were selected. Then the mRNA levels of BDNF, Caspase - 3 and Tuj - 1 were detected in both groups by quantitative polymerase chain reaction ( RT - PCR) . Results The study group had higher Caspase - 3 mRNA expression level ( P < 0. 01 ) as well as lower BDNF and Tuj - 1 ( P < 0. 05 or 0. 01 ) mRNA expression levels than those of the control group. Conclusion The BDNF and Tuj - 1 mRNA expression levels are down - regulated, meanwhile the Caspase - 3 mRNA expression level is up - regulated in schizophrenic children, indicating that the three indicators may be related to the onset of schizophrenia. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |