| 张婕,卓丽华,唐春耕.轻度创伤性脑损伤后脑组织微环境变化：多模态磁共振成像研究[J].四川精神卫生杂志,2019,32(3):223-227.,Micro-environmental changes in brain tissue after mild traumatic brain injury: a multimodal functional magnetic resonance imaging study[J].SICHUAN MENTAL HEALTH,2019,32(3):223-227 |
| 轻度创伤性脑损伤后脑组织微环境变化：多模态磁共振成像研究 |
| Micro-environmental changes in brain tissue after mild traumatic brain injury: a multimodal functional magnetic resonance imaging study |
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| DOI：10.11886/j.issn.1007-3256.2019.03.006 |
| 中文关键词: 磁共振波谱学 弥散张量成像 轻度创伤性脑损伤 磁敏感加权成像 |
| 英文关键词:Magnetic resonance spectroscopy Diffusion tensor imaging Mild traumatic brain injury Magnetic sensitive weighted imaging |
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| 【摘要】 目的 探讨弥散张量成像(DTI)联合磁共振波谱(MRS)及磁敏感加权成像(SWI)的功能磁共振成像方法,在评估轻度创伤性脑损伤(mTBI)脑组织代谢及微结构变化的应用价值,为临床制定相应的治疗方案提供影像学参考?方法 纳入21例 mTBI患者和 16例健康志愿者,mTBI患者在伤后 4~72h内接受 T1WI?T2WI?FLAIR?DTI?MRS及 SWI序列扫描,通过各序列图像及参数值评估mTBI患者伤侧脑组织和对照组内囊前肢?内囊后肢?胼胝体膝部?胼胝体压部?扣带回?半卵圆中心?额叶白质及视辐射的差异?结果 两组FA值比较,仅胼胝体压部差异有统计学意义(P<0.01)?mTBI组胼胝体膝部NAA/Cr值低于对照组,差异有统计学意义(P<0.01)?mTBI组内囊后肢和胼胝体膝部 Cho/Cr值均高于对照组,差异均有统计学意义(P<0.05或 0.01)?结论 FA值及 NAA?Cho?Cr值能测定 mTBI后脑组织水分子扩散及代谢情况,DTI联合 MRS及SWI可以作为一项客观指标,定量评估 mTBI患者的病情及预后? |
| 英文摘要: |
| Objective To investigate the application value of diffusion tensor imaging ( DTI ) combined with magnetic resonance spectroscopy ( MRS) and magnetic sensitive weighted imaging ( SWI) functional magnetic resonance imaging in the assessment of brain tissue metabolism and micro - structural changes after mild traumatic brain injury ( mTBI) , and to provide imaging basis for choosing appropriate treatment options. Methods 21 patients with mTBI and 16 healthy volunteers were enrolled in this study.Patients underwent T1 WI, T2WI, FLAIR, DTI, MRS and SWI sequence scans within 4 ~ 72 hours after injury. The patients with mTBI were evaluated by sequence images and parameter values. The difference among the anterior capsule of the injured side, the hindlimb of the internal capsule, the knee of the corpus callosum, the pressure of the corpus callosum, the cingulate gyrus, the semi - oval center, the white matter of the frontal lobe and the visual radiation were examined. Results Compared with the FA values of the two groups, only FA of the corpus callosum was statistically significant different ( P < 0. 01 ) . The NAA /Cr values in the knees of the mTBI group were significantly lower than those in the control group ( P < 0. 01 ) . The Cho /Cr value in the hind limbs and the corpus callosum were significantly higher in the mTBI group than that in the control group( P < 0. 05 or 0. 01 ) . Conclusion FA value and NAA, Cho, and Cr values may quantitatively determine the diffusion and metabolism of water molecules in brain tissue after mTBI. DTI combined with MRS and SWI could be used as an objective index to quantitatively evaluate the condition and prognosis of patients with mTBI. |
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