| 朱晓昱,朱瑜,韩笑乐.精神分裂症患者的肠 －脑轴研究进展[J].四川精神卫生杂志,2019,32(4):363-366.,Research progress of gut-brain axis in schizophrenia[J].SICHUAN MENTAL HEALTH,2019,32(4):363-366 |
| 精神分裂症患者的肠 －脑轴研究进展 |
| Research progress of gut-brain axis in schizophrenia |
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| DOI：10.11886/j.issn.1007-3256.2019.04.017 |
| 中文关键词: 精神分裂症 肠-脑轴 微生物 谷氨酸 多巴胺 治疗抵抗 |
| 英文关键词:Schizophrenia Gut-brainaxis Microbiotas Glutamate Dopamine Therapy resistance |
| 基金项目:北京市卫生系统高层次卫生技术人才培养计划(2015-3-111) |
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| 中文摘要: |
| 【摘要】 本文目的是探讨肠道微生物、肠-脑轴与精神分裂症的关系，为精神分裂症的治疗开辟新思路。精神分裂症发病机制目前尚未完全阐明，有假说及研究发现，精神分裂症的发生和发展均与病原微生物有关，特别是人体神经系统的肠-脑轴在其中扮演了重要角色。肠道微生物群通过释放和分泌功能性神经递质，影响中枢神经系统的相关神经递质水平，从而改变宿主的情绪、行为和精神状态。本文对近年来关于微生物、肠 －脑轴与精神分裂症的研究进展进行综述，讨论肠道细菌与宿主之间的关系。 |
| 英文摘要: |
| The purpose of this article is to discuss the relationship between intestinal microorganisms, gut-brain axis and schizophrenia, and to inspire new ideas on the treatment of schizophrenia.The pathogenesis of schizophrenia still remains obscure,meanwhile, the hypotheses and studies have found that the onset and treatment response of schizophrenia are related to pathogenic microorganisms, especially the intestinal-brain axis of the human nervous system.The intestinal microbiota affects the mood,
behavior,and mental state of the host by releasing and secreting functional neurotransmitters that affect the levels of neurotransmitters associated with the central nervous system.This article reviews recent advances in microbiology, gut-brain axis and schizophrenia,and discusses the relationship between gut bacteria and host. |
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