| 韦臻,余嘉盛,阮中强,阳琼.强迫症患者前瞻记忆缺损程度对SSRIs疗效的预测作用[J].四川精神卫生杂志,2021,34(4):336-340.Wei Zhen,Yu Jiasheng,Ruan Zhongqiang,Yang Qiong,Predictive role of the degree of prospective memory impairment on treatment response to SSRIs in patients with obsessive-compulsive disorder[J].SICHUAN MENTAL HEALTH,2021,34(4):336-340 |
| 强迫症患者前瞻记忆缺损程度对SSRIs疗效的预测作用 |
| Predictive role of the degree of prospective memory impairment on treatment response to SSRIs in patients with obsessive-compulsive disorder |
| 投稿时间：2021-05-12 |
| DOI：10.11886/scjsws20210512001 |
| 中文关键词: 强迫症 前瞻记忆 SSRIs 预测疗效 |
| 英文关键词:Obsessive-compulsive disorder Prospective memory SSRIs Outcome prediction |
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| 中文摘要: |
| 目的 探究强迫症患者前瞻记忆缺损程度对选择性5-羟色胺再摄取抑制剂（SSRIs）疗效的预测作用。方法 选择符合《精神障碍诊断与统计手册（第4版）》修订版（DSM-IV-TR）强迫症诊断标准的30例强迫症患者为研究对象，对患者进行为期4周的SSRIs药物治疗。采用耶鲁布朗强迫症状量表（Y-BOCS）评定患者治疗前后强迫症状的严重程度，以Y-BOCS总评分减分率评定疗效，并比较患者治疗前后基于事件、基于时间和基于活动的前瞻记忆任务正确率。结果 治疗后，强迫症患者Y-BOCS总评分低于治疗前［（27.07±4.63）分vs.（24.87±5.93）分，F（1，29）=4.984，P=0.033］，基于事件和基于时间的前瞻记忆任务正确率高于治疗前［（0.78±0.21）vs.（0.88±0.11），F（1，29）=9.022，P=0.005；（0.81±0.17）vs.（0.91±0.11），F（1，29）=9.063，P=0.005］，患者基线基于事件的前瞻记忆任务正确率与Y-BOCS总评分减分率呈正相关（r=0.478，P=0.014），基线基于事件的前瞻记忆水平可正向预测SSRIs疗效（β=0.441，P=0.014）。结论 强迫症患者基线基于事件的前瞻记忆水平可预测SSRIs疗效，前瞻记忆水平越高，SSRIs疗效越好。 |
| 英文摘要: |
| Objective To explore the predictive role of the degree of prospective memory impairment on the treatment response to Selective Serotonin Reuptake Inhibitors （SSRIs） in patients with obsessive-compulsive disorder.Methods A total of 30 patients with obsessive-compulsive disorder who met the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders， fourth edition， text revision （DSM-IV-TR） were selected， and all patients were treated with SSRIs for 4 weeks. The severity of obsessive-compulsive symptom was assessed using Yale-Brown Obsessive Compulsive Scale （Y-BOCS）， and the efficacy was evaluated by the reduction rate of Y-BOCS score. Moreover， the performance of event-based， time-based and activity-based prospective memory tasks were compared before and after treatment.Results After treatment， the total Y-BOCS score of patients was lower than before treatment ［（27.07±4.63） vs. （24.87±5.93）， F（1，29）=4.984， P=0.033］， meantime， the performance of event- and time- based prospective memory tasks was improved ［（0.78±0.21） vs. （0.88±0.11）， F（1，29）=9.022， P=0.005； （0.81±0.17） vs. （0.91±0.11）， F（1，29）=9.063， P=0.005］. Correlation analysis showed that the performance of event-based prospective memory at baseline was positively correlated with the reduction of Y-BOCS score （r=0.478， P=0.014）. The event-based prospective memory performance at baseline could positively predict the treatment response to SSRIs treatment in patients （β=0.441， P=0.014）.Conclusion The event-based prospective memory function of patients with obsessive-compulsive disorder can positively predict SSRIs treatment outcome， and patients with better prospective memory performance yield better treatment responses. |
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