| 李凌江.抑郁障碍临床研究的基本科学问题[J].四川精神卫生杂志,2021,34(6):494-497.Li Lingjiang,Basic scientific issues in clinical research of depressive disorder[J].SICHUAN MENTAL HEALTH,2021,34(6):494-497 |
| 抑郁障碍临床研究的基本科学问题 |
| Basic scientific issues in clinical research of depressive disorder |
| 投稿时间：2021-11-17 |
| DOI：10.11886/scjsws20211117002 |
| 中文关键词: 抑郁障碍 诊断 治疗 困惑 |
| 英文关键词:Depressive disorder Diagnosis Treatment Issues |
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| 中文摘要: |
| 本文目的是探讨抑郁障碍两个最核心的临床问题：诊断与治疗。抑郁症患病率高且是当前最重要的精神疾病，如何进行确切的诊断与有效的治疗是临床亟需解决的问题。本文从抑郁障碍诊断和治疗的现状与困惑四个维度进行了探讨，重点介绍了抑郁症的治疗，虽然有困难，但从STAR*D研究结果来看，现有的治疗方法可以使三分之二的患者达到临床痊愈，而且随着研究的不断深入，新的理论和假说被提出，并开发出了很多新药物，尤其为难治性抑郁症和急性期抑郁症患者带来了希望。 |
| 英文摘要: |
| The purpose of this paper is to explore the two critical issues， clinical diagnosis and treatment of depressive disorder. As the most prevalent and prominent psychiatric disorder， it is an urgent clinical issue to be addressed in terms of accurate diagnosis and effective treatment. The article explores four dimensions， the current state and confusion in clinical diagnosis versus treatment， with emphasis on the treatment of depressive disorder. Despite the difficulties， Sequenced Treatment Alternatives to Relieve Depression （STAR*D） study proclaims that the existing therapies results in clinical cures in two-thirds of evaluable patients. As research continues， new theories and hypotheses are being proposed and many new drugs are being developed， offering hope especially for patients with refractory depression and acute depression. |
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