| 张文炎,李龙飞,宋小慧,李武.抗精神病药物对精神分裂症患者血尿酸水平影响的Meta分析[J].四川精神卫生杂志,2021,34(6):522-528.Zhang Wenyan,Li Longfei,Song Xiaohui,Li Wu,Effect of antipsychotics on serum uric acid in patients with schizophrenia： a Meta-analysis[J].SICHUAN MENTAL HEALTH,2021,34(6):522-528 |
| 抗精神病药物对精神分裂症患者血尿酸水平影响的Meta分析 |
| Effect of antipsychotics on serum uric acid in patients with schizophrenia： a Meta-analysis |
| 投稿时间：2021-05-20 |
| DOI：10.11886/scjsws20210520001 |
| 中文关键词: 氧化应激 精神分裂症 血尿酸 抗精神病药物 Meta分析 |
| 英文关键词:Oxidative stress Schizophrenia Serum uric acid Antipsychotics Meta-analysis |
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| 中文摘要: |
| 目的 探讨抗精神病药物对精神分裂症患者血尿酸水平的影响，明确抗精神病药物抗氧化性，为精神分裂症的治疗提供循证参考。方法 采用主题词+自由词的方式，计算机检索PubMed、Embase、Web of Science、Cochrane Library、中国知网、万方数据库、维普数据库、中国生物医学文献数据库，纳入抗精神病药物对精神分裂症患者血尿酸水平影响的对照研究。采用RevMan 5.4进行Meta分析。结果 纳入中英文文献共15篇，包括9种抗精神病药、1 434例精神分裂症患者。Meta分析结果显示，奥氮平（MD=14.01，95% CI：2.39~21.62，P<0.05）和氯丙嗪（MD=51.36，95% CI：42.15~60.57，P<0.05）可升高精神分裂症患者血尿酸水平，利培酮、阿立哌唑、氯氮平、氟哌啶醇、喹硫平和齐拉西酮对精神分裂症患者血尿酸水平的影响均无统计学意义（P均>0.05）。结论 不同种类的抗精神病药对精神分裂症患者血尿酸水平的影响不同，其中奥氮平和氯丙嗪可升高精神分裂症患者血尿酸水平，尚未发现其他抗精神病药物对患者血尿酸水平的影响。 |
| 英文摘要: |
| Objective To investigate the impact of antipsychotics on serum uric acid level in patients with schizophrenia， and to clarify the antioxidant properties of antipsychotics， so as to provide evidence-based guidelines for the treatment of schizophrenia.Methods Keywords combined with free-text search strategies were used to retrieve English and Chinese databases including PubMed， Embase， Web of Science， Cochrane Library， CNKI， Wanfang Database， VIP database and Chinese Biomedical Literature Database. Randomized controlled trials related to the effects of antipsychotics on serum uric acid level in patients with schizophrenia were included. Meta-analysis was performed using RevMan 5.3.Results A total of 9 kinds of antipsychotics and 1 434 schizophrenia patients in 15 Chinese and English literatures were included. Meta-analysis showed that olanzapine （MD=14.01， 95% CI： 2.39~21.62， P<0.05） and chlorpromazine （MD=51.36， 95% CI： 42.15~60.57， P<0.05） increased the serum uric acid level in schizophrenia patients， while risperidone， aripiprazole， clozapine， haloperidol， quetiapine and ziprasidone had no significant effect on serum uric acid （P>0.05）.Conclusion The effect of different kinds of antipsychotics on serum uric acid level in schizophrenia patients varies， among which olanzapine and chlorpromazine can elevate serum uric acid level in patients with schizophrenia， whereas no other antipsychotics have been found to have any effect on serum uric acid level. |
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