| 吴海龙,张振清,卢大力.舍曲林联合小剂量阿立哌唑治疗儿童青少年强迫性障碍的随机对照研究[J].四川精神卫生杂志,2021,34(6):529-532.Wu Hailong,Zhang Zhenqing,Lu Dali,Sertraline combined with low-dose aripiprazole in the treatment of obsessive-compulsive disorder in children and adolescents： a randomized controlled study[J].SICHUAN MENTAL HEALTH,2021,34(6):529-532 |
| 舍曲林联合小剂量阿立哌唑治疗儿童青少年强迫性障碍的随机对照研究 |
| Sertraline combined with low-dose aripiprazole in the treatment of obsessive-compulsive disorder in children and adolescents： a randomized controlled study |
| 投稿时间：2021-04-28 |
| DOI：10.11886/scjsws20210428001 |
| 中文关键词: 舍曲林 阿立哌唑 儿童 强迫性障碍 |
| 英文关键词:Sertraline Aripiprazole Children and adolescents Obsessive-compulsive disorder |
| 基金项目:厦门市科技计划指导性项目（项目名称：舍曲林合并阿立哌唑治疗儿童强迫症的随机对照研究，项目编号：3502Z20179003） |
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| 目的 探讨舍曲林联合小剂量阿立哌唑治疗儿童青少年强迫性障碍的效果和安全性。方法 选取2018年6月-2020年5月于厦门市某精神病专科医院门诊就诊、符合《国际疾病分类（第10版）》（ICD-10）强迫性障碍诊断标准的9~16岁儿童青少年患者62例为研究对象，采用完全随机法分为研究组（n=32）与对照组（n=30），对照组采用舍曲林单药治疗，研究组采用舍曲林联合小剂量阿立哌唑治疗。于治疗前和治疗第2、4、8、12周末采用耶鲁-布朗强迫量表儿童版（CY-BOCS）评定患儿的强迫症状，采用副反应量表（TESS）评定药物不良反应，比较两种治疗方法在疗效及不良反应的差异。结果 治疗第2、4周末，研究组CY-BOCS强迫行为维度评分均低于对照组，差异均有统计学意义（t=-2.083、-2.176，P均<0.05）；治疗第2周末，研究组治疗有效率（40.63%）高于对照组（3.33%），差异有统计学意义（χ2=12.317，P<0.01）；截止到治疗12周末，两组不良反应发生率差异无统计学意义（χ2=1.608，P=0.205）。结论 舍曲林联合小剂量阿立哌唑治疗可能有助于更快改善儿童青少年强迫性障碍的强迫行为，而联合用药与单用舍曲林安全性相当。 |
| 英文摘要: |
| Objective To investigate the efficacy and safety of sertraline combined with low-dose aripiprazole in the treatment of obsessive-compulsive disorder in children and adolescents.Methods A total of 62 cases pediatric patients aged 9~16 years who attended the outpatient clinic of a psychiatric hospital in Xiamen from June 2018 to May 2020 and met the diagnostic criteria of International Classification of Diseases， tenth edition （ICD-10） for obsessive-compulsive disorder were enrolled in the study. The selected children were randomly classified into two groups for different treatments. Control group （n=30） received sertraline monotherapy， and study group （n=32） received sertraline combined with low-dose aripiprazole treatment. At the baseline and the end of the 2nd， 4th， 8th and 12th weeks of treatment， children were assessed using Children's Yale-Brown Obsessive Compulsive Scale （CY-BOCS） and Treatment Emergent Symptoms Scale （TESS）. Thereafter， the clinical efficacy and adverse reactions were compared between two groups.Results The compulsive behavior dimensional score of CY-BOCS of study group was lower than that of control group at end of the 2nd and 4th weeks of treatment （t=-2.083， -2.176， P<0.05）. At the end of the 2nd week of treatment， the effective rate was 40.63% in study group， which was significantly higher than 3.33% in control group （χ2=12.317， P<0.01）. By the end of the 12th weeks of treatment， the incidence rate of side effects yielded no statistical difference between two groups （χ2=1.608， P=0.205）.Conclusion Compared with sertraline monotherapy， its combination with low-dose aripiprazole treatment can effectively accelerate the improvement of clinical symptoms in childrenand adolescents with obsessive-compulsive disorder， while the combination therapy and sertraline monotherapy have equivalent safety. |
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