| 任俊赏,蒲澜.高频重复经颅磁刺激联合舍曲林治疗儿童青少年抑郁发作的临床对照研究[J].四川精神卫生杂志,2022,35(2):153-156.Ren Junshang,Pu Lan,Clinical controlled study of high-frequency repeated transcranial magnetic stimulation combined with sertraline in the treatment of depression in children and adolescents[J].SICHUAN MENTAL HEALTH,2022,35(2):153-156 |
| 高频重复经颅磁刺激联合舍曲林治疗儿童青少年抑郁发作的临床对照研究 |
| Clinical controlled study of high-frequency repeated transcranial magnetic stimulation combined with sertraline in the treatment of depression in children and adolescents |
| 投稿时间：2022-03-23 |
| DOI：10.11886/scjsws20220323002 |
| 中文关键词: 儿童青少年 抑郁发作 舍曲林 高频重复经颅磁刺激 对照研究 |
| 英文关键词:Children and adolescents Depression episodes Sertraline High-frequency repetitive transcranial magnetic stimulation Control study |
| 基金项目: |
|
| 摘要点击次数: |
| 全文下载次数: |
| 中文摘要: |
| 目的 分析高频重复经颅磁刺激（rTMS）联合舍曲林治疗儿童青少年抑郁发作的效果和安全性。方法 选取2019年11月-2020年5月天水市第三人民医院连续收治的107例符合《国际疾病分类（第10版）》（ICD-10）抑郁发作诊断标准的儿童青少年患者为研究对象，按照随机数字表法分为研究组（n=53）和对照组（n=54）。两组均接受为期4周的舍曲林治疗，研究组在此基础上接受高频rTMS（10 Hz）治疗。于基线期、治疗第1、2、3、4周末采用汉密尔顿抑郁量表24项版（HAMD-24）评定疗效，于治疗第1、2、3、4周末采用副反应量表（TESS）评定不良反应。结果 研究组和对照组完成研究者均为50例。治疗第1、2、3、4周末，研究组HAMD-24评分均低于对照组（t=2.556~3.434，P均<0.05）。治疗第4周末，研究组治疗总有效率高于对照组，差异有统计学意义（90.00% vs. 78.00%，χ2=2.680，P<0.05），且研究组和对照组不良反应发生率差异无统计学意义（30.00% vs. 26.00%，χ2=0.200，P>0.05）。结论 与单用舍曲林相比，高频rTMS联合舍曲林治疗儿童青少年抑郁发作的效果更好，二者安全性相当。 |
| 英文摘要: |
| Objective To evaluate the efficacy and safety of high frequency repetitive transcranial magnetic stimulation （rTMS） combined with sertraline in the treatment of depression in children and adolescents.Methods From November 2019 to May 2020， a sample of 107 children and adolescents who met the diagnostic criteria of International Classification of Diseases， tenth edition （ICD-10 ） for depressive episode were selected from the Third People's Hospital of Tianshui. According to the method of random number table， individuals were classified into study group（n=53） and control group（n=54）. All subjects received sertraline treatment， based on this， study group received high-frequency rTMS （10 Hz）. Treatment in both groups lasted for 4 weeks. Efficacy was assessed using Hamilton Depression Scale-24 item （HAMD-24） at the baseline， and the end of the 1st， 2nd， 3rd and 4th weeks of treatment， and adverse reactions were evaluated via Treatment Emergent Symptom Scale （TESS） at the 1st， 2nd， 3rd and 4th weekend of treatment.Results There were 50 participants in both the study group and control group. The HAMD-24 score of study group were lower than those of control group at the end of 1st， 2nd， 3rd and 4th weeks of treatment （t=2.556~3.434， P<0.05）. The overall efficacy rate at the 4th week of treatment was 90.00% in study group， which was significantly higher than 78.00% in control group （χ2=2.680， P<0.05）. The adverse reaction rate yielded no statistical difference between study group and control group （30.00% vs. 26.00%， χ2=0.200， P>0.05）.Conclusion Compared with sertraline treatment alone， its combination with high-frequency rTMS achieves better outcomes in the treatment of depression in children and adolescents， without compromising safety. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |