孙振晓,刘化学.齐拉西酮致口吃1例[J].四川精神卫生杂志,2022,35(4):373-375.Sun Zhenxiao,Liu Huaxue,Ziprasidone-induced stuttering: a case report[J].SICHUAN MENTAL HEALTH,2022,35(4):373-375
齐拉西酮致口吃1例
Ziprasidone-induced stuttering: a case report
投稿时间:2022-04-22  
DOI:10.11886/scjsws20220422002
中文关键词:  齐拉西酮  口吃  不良反应
英文关键词:Ziprasidone  Stuttering  Side effect
基金项目:
作者单位邮编
孙振晓* 临沂市精神卫生中心山东 临沂 276005 276005
刘化学 临沂市精神卫生中心山东 临沂 276005 276005
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中文摘要:
      本文报告了一例25岁男性精神分裂症患者接受奥氮平联合苯海索治疗,精神症状缓解。因又出现幻听,故加用齐拉西酮治疗,4天后患者出现口吃,停用齐拉西酮2天后口吃消失,再次加用齐拉西酮后口吃又出现,停用后口吃消失。遂将奥氮平增至20 mg/d治疗,精神症状渐稳定。4个月后复诊,患者精神症状稳定,未再出现口吃,提示系齐拉西酮所致口吃。本案例提示:临床上在应用齐拉西酮时,应考虑到其引起口吃的可能性。
英文摘要:
      This paper reported a case of a 25-year-old male schizophrenic patient, who obtained remission from psychotic symptoms during the treatment of olanzapine and trihexylphenidyl, was given ziprasidone treatment additionally due to the occurrence of auditory hallucination, and developed stuttering 4 days later. The stuttering disappeared 2 days following the discontinuation of therapy, and reappeared after reinstitution of ziprasidone therapy, but disappeared again after discontinuation. The dose of olanzapine was increased to 20 mg/d to ensure the stability of psychotic remission. At a follow-up visit 4 months later, the patient’s mental condition was stable and stuttering did not recur, indicating that the stuttering was induced by ziprasidone. This case suggests that the possibility of stuttering as an adverse reaction should be considered in the clinical application of ziprasidone.
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