| 曲伊平,黄琳,孛伟男,王晓一,姜宝顺,陈允恩.重复经颅磁刺激对青少年抑郁症患者的疗效及认知功能的影响[J].四川精神卫生杂志,2023,36(1):19-24.Qu Yiping,Huang Lin,Bo Weinan,Wang Xiaoyi,Jiang Baoshun,Chen Yunen,Effect of rTMS on the efficacy and cognitive function of adolescents with depression[J].SICHUAN MENTAL HEALTH,2023,36(1):19-24 |
| 重复经颅磁刺激对青少年抑郁症患者的疗效及认知功能的影响 |
| Effect of rTMS on the efficacy and cognitive function of adolescents with depression |
| 投稿时间：2022-07-25 |
| DOI：10.11886/scjsws20220725002 |
| 中文关键词: 青少年 抑郁症 认知功能 重复经颅磁刺激 |
| 英文关键词:Adolescents Depression Cognitive function Repetitive transcranial magnetic stimulation |
| 基金项目:河北省卫生健康委医学科学研究课题计划项目（项目名称：电针联合rTMS治疗焦虑抑郁障碍临床研究，项目编号：20181457） |
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| 中文摘要: |
| 目的 探讨重复经颅磁刺激（rTMS）对青少年抑郁症患者的疗效及认知功能的影响。方法 选取华北理工大学附属医院心理门诊2021年9月-2022年3月连续收治的符合《国际疾病分类（第10版）》（ICD-10）诊断标准的60例青少年抑郁症患者为研究对象，采用随机数字表法分为研究组（草酸艾司西酞普兰联合rTMS治疗）和对照组（草酸艾司西酞普兰联合rTMS伪刺激治疗）各30例，两组均治疗4周。在治疗前和治疗1、2、3、4周，采用汉密尔顿抑郁量表24项版（HAMD-24）评分及减分率评定患者的抑郁症状；治疗前和治疗4周后，采用智蕴神经心理自动化测验系统中的运动筛查任务（MOT）、规则转换任务（RST）、延迟性样本匹配（DMS）任务进行认知功能评估；记录两组治疗期间的不良反应情况。结果 重复测量方差分析结果显示，患者治疗前和治疗1、2、3、4周后，两组HAMD-24评分的时间主效应、组别主效应以及二者交互作用均有统计学意义（F=522.021、39.905、26.412，P均<0.05）。单独效应分析显示，治疗2、3、4周后，两组HAMD-24评分差异有统计学意义（t=-12.784~-2.776，P均<0.01）。治疗4周后，研究组的治疗总有效率高于对照组（93.33% vs.73.33%，χ2=4.320，P<0.05），两组RST、DMS各指标与治疗前相比差异均有统计学意义（t=-5.616~9.135，P?0.05或0.01），且两组组间的差异有统计学意义（t=-4.823~5.518，P<0.05或0.01）。结论 rTMS可能有助于改善青少年抑郁症患者的抑郁症状及认知功能。 |
| 英文摘要: |
| Objective To investigate the effects of repetitive transcranial magnetic stimulation （rTMS） on the efficacy and cognitive function of adolescents with depression.Methods A total of sixty adolescent depression patients who met the diagnostic criteria of the International Classification of Diseases， tenth edition （ICD-10） and were admitted to the psychological outpatient clinic of the Affiliated Hospital of North China University of Technology from September 2021 to March 2022 were selected for the study， and the random number table method was used to divide the study group （escitalopram oxalate combined with rTMS treatment） and a control group （escitalopram oxalate combined with rTMS pseudo-stimulation treatment） of 30 cases each， and both groups were treated for 4 weeks. Before treatment and at 1， 2， 3 and 4 weeks of treatment， patients' depressive symptoms were assessed using the scores and subtraction rates of the Hamilton Depression Scale-24 item （HAMD-24）， and before treatment and after 4 weeks of treatment， cognitive function was assessed using the Motion Screening Task （MOT）， Rule Switch Task （RST） and Delayed Matching-to-Sample （DMS） task of the Zhiyun Neuropsychological Automated Test System assessment. Adverse effects during treatment were recorded in both groups.Results Repeated measures ANOVA results showed statistically significant time main effects， group main effects， and the interaction between the two groups for HAMD-24 scores before treatment and after 1， 2， 3 and 4 weeks of treatment in patients （F=522.021， 39.905， 26.412， P<0.05）. Individual effect analysis showed statistically significant differences in HAMD-24 scores between the two groups after 2， 3 and 4 weeks of treatment （t=-12.784~-2.776， P<0.01）. After 4 weeks of treatment， the total effective rate of treatment in the study group was higher than that in the control group （93.33% vs. 73.33%， χ2=4.320， P<0.05）， and the differences in each indicator of RST and DMS between the two groups were statistically significant compared with those before treatment （t=-5.616~9.135， P<0.05 or 0.01）， and the differences between the two groups were statistically significant （t=-4.823~5.518， P<0.05 or 0.01）.Conclusion rTMS may help improve depressive symptoms as well as cognitive function in adolescents with depression. |
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