| 郝可可,王惠玲,王高华.线粒体功能障碍与神经炎症在精神分裂症发病机制中的研究进展[J].四川精神卫生杂志,2023,36(1):74-79.Hao Keke,Wang Huiling,Wang Gaohua,Advances in the study of the roles of mitochondrial dysfunction and neuroinflammation in the pathogenesis of schizophrenia[J].SICHUAN MENTAL HEALTH,2023,36(1):74-79 |
| 线粒体功能障碍与神经炎症在精神分裂症发病机制中的研究进展 |
| Advances in the study of the roles of mitochondrial dysfunction and neuroinflammation in the pathogenesis of schizophrenia |
| 投稿时间：2022-07-21 |
| DOI：10.11886/scjsws20220721001 |
| 中文关键词: 精神分裂症 免疫炎症 线粒体 小胶质细胞 |
| 英文关键词:Schizophrenia Immuno-inflammation Mitochondria Microglia |
| 基金项目:武汉大学医学腾飞计划（神经科学疾病与功能协同创新平台）（项目编号：TFLC2018001，项目名称：基于多模态神经影像遗传学的精神分裂症发病机制及其治疗反应研究） |
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| 中文摘要: |
| 本文目的是综述线粒体功能障碍与小胶质细胞炎症在精神分裂症相关病理生理机制中的研究进展。精神分裂症是一种严重的精神疾病，免疫炎症途径被认为是其主要的发病机制之一，表现为脑内小胶质细胞激活和炎症因子水平升高。然而，导致精神分裂症免疫紊乱的生物学机制尚未完全阐明。越来越多的证据表明，线粒体功能障碍可能在精神分裂症的发病机制中起关键作用。本文通过对线粒体功能障碍与小胶质细胞炎症在精神分裂症病理生理机制中的研究进展进行综述，为精神分裂症的发病机制研究提供参考。 |
| 英文摘要: |
| This paper aims to present a review of the research progress on the roles of mitochondrial dysfunction and microglia-mediated inflammation in the pathophysiology of schizophrenia. Schizophrenia is a serious psychiatric disorder in which the immuno-inflammatory pathway is considered to be one of the main pathogenic mechanisms of disease， and manifested by microglia activation and elevated levels of inflammatory cytokines in the brain. However， the biological mechanism underlying immune disorder in schizophrenia has not been fully elucidated. In recent years， accumulating evidence has indicated that mitochondrial dysfunction may play a key role in the pathogenesis of schizophrenia. Therefore， this article reviews the research progress on the roles of mitochondrial days function and microglia-mediated inflammation in the pathophysiology of schizophrenia， so as to inform the study of the pathogenesis of schizophrenia. |
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