| 陈新宇,陈传传,罗蓓,曲帅,王国强,张凯.辅助生殖技术对儿童体格和孤独症行为的影响：一项3年纵向随访研究[J].四川精神卫生杂志,2023,36(5):428-432.Chen Xinyu,Chen Chuanchuan,Luo Bei,Qu Shuai,Wang Guoqiang,Zhang Kai,Effects of assisted reproductive technology on physique and autistic behavior of children： a 3-year longitudinal follow-up study[J].SICHUAN MENTAL HEALTH,2023,36(5):428-432 |
| 辅助生殖技术对儿童体格和孤独症行为的影响：一项3年纵向随访研究 |
| Effects of assisted reproductive technology on physique and autistic behavior of children： a 3-year longitudinal follow-up study |
| 投稿时间：2022-10-26 |
| DOI：10.11886/scjsws20221026001 |
| 中文关键词: 辅助生殖技术 儿童 体格发育 神经发育 |
| 英文关键词:Assisted reproductive technology Children Physical development Neurological development |
| 基金项目:安徽省教育厅高校优秀青年人才支持计划重点项目（项目编号：gxyqZD2022022） |
|
| 摘要点击次数: |
| 全文下载次数: |
| 中文摘要: |
| 背景 辅助生殖技术日益成熟，并广泛应用于临床。辅助生殖技术诞生的新生儿越来越多，这类儿童的健康问题也需要更多关注。目的 探讨辅助生殖技术对儿童体格和孤独症行为的影响，提高对辅助生殖儿童孤独症行为的关注度。方法 从病历信息系统中，按时间顺序选取2018年8月-2019年8月在安徽医科大学附属巢湖医院产科出生的辅助生殖新生儿（辅助生殖组）588例为研究对象。从病历信息系统中选取同一时间段该院产科自然受孕出生的600名新生儿为对照组。收集所有新生儿的性别、出生时母亲的年龄和受教育年限、出生孕周、出生体质量、出生身长以及3岁时体质量和身高数据，并在3岁随访时进行克氏孤独症行为量表（CABS）评定。结果 辅助生殖组母亲受教育年限长于对照组母亲受教育年限［（12.04±1.96）年vs.（11.34±2.90）年，t=-4.887，P<0.01］，出生孕周和出生体质量均低于对照组［（38.68±2.56）周vs.（39.53±2.91）周，t=5.315，P<0.01，（3 273.27±720.39）g vs.（3 158.29±701.74）g，t=2.792，P<0.05］。两组出生身长差异无统计学意义［（49.97±5.94）cm vs.（50.07±6.08）cm，t=-0.287，P>0.05］。3岁时，辅助生殖组体质量和身高均低于对照组［（16.16±2.53）kg vs.（16.96±1.67）kg，t=6.393，P<0.01，（95.81±4.50）cm vs.（97.47±7.49）cm，t=4.626，P<0.01］。对照组和辅助生殖组分别筛查出6例（1.00%）和15例（2.55%）存在孤独症行为，差异有统计学意义（χ2=4.113，P<0.05）。结论 辅助生殖技术可能对儿童体格和神经发育存在影响。 |
| 英文摘要: |
| Background Assisted reproductive technology is increasingly mature and widely used in clinic. As more and more newborns are born with assisted reproductive technology， the health problems of these newborns also need more attention.Objective To investigate the effects of assisted reproductive technology on newborn physique and autistic behavior， and to raise the attention of autistic behavior of assisted reproductive children.Methods From the medical record information system， 588 assisted reproduction newborns （assisted reproduction group） born in the obstetrics department of Chaohu Hospital of Anhui Medical University from August 2018 to August 2019 were selected as the study objects. From the medical records information system， 600 newborns born naturally in the obstetrics department in the same period of time were selected as the control group. The basic information of all newborns was collected， including the mother's age and years of education， sex， gestational age， birth weight and birth length， and they were assessed by the Clancy Autism Behavior Scale （CABS） at 3 years of follow-up.Results The educational years of mothers in assisted reproduction group were longer than those in control group ［（12.04±1.96） years vs. （11.34±2.90） years， t=-4.887， P<0.01］， gestational age and birth weight of assisted reproduction group were lower than those of control group ［（38.68±2.56） weeks vs. （39.53±2.91） weeks， t=5.315， P<0.01； （3 273.27±720.39） g vs. （3 158.29±701.74） g， t=2.792， P<0.05］. There was no significant difference in birth length between the two groups ［（49.97±5.94） cm vs. （50.07±6.08） cm， t=-0.287， P>0.05］. At the age of three， the weight and height of the assisted reproduction group were both lower than those of the control group ［（16.16±2.53）kg vs.（16.96±1.67）kg， t=6.393， P<0.01， （95.81±4.50）cm vs.（97.47±7.49）cm， t=4.626， P<0.01］. Respectively， 6 （1.00%） and 15 （2.55%） children with autism were detected in the control group and assisted reproduction group， and the difference was statistically significant （χ2=4.113， P<0.05）.Conclusion Assisted reproductive technology may affect the physical and neurological development of children. ［Funded by Outstanding Young Talents Support Program of Anhui Education Department （number， gxyqZD2022022）］ |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |