| 耿艳红,王媺媞,刘凤菊,徐逸,汪崇泽,范小荷,吕钦谕,马玮亮,洪武.抑郁障碍患者精神运动性迟滞与血浆G-CSF、M-CSF水平的相关性[J].四川精神卫生杂志,2023,36(6):485-490.Geng Yanhong,Wang Meiti,Liu Fengju,Xu Yi,Wang Chongze,Fan Xiaohe,Qinyu Lyv,Ma Weiliang,Hong Wu,Correlation of psychomotor retardation with plasma G-CSF and M-CSF levels in patients with major depressive disorder[J].SICHUAN MENTAL HEALTH,2023,36(6):485-490 |
| 抑郁障碍患者精神运动性迟滞与血浆G-CSF、M-CSF水平的相关性 |
| Correlation of psychomotor retardation with plasma G-CSF and M-CSF levels in patients with major depressive disorder |
| 投稿时间：2023-02-19 |
| DOI：10.11886/scjsws20230219002 |
| 中文关键词: 抑郁障碍 精神运动性迟滞 细胞因子 粒细胞集落刺激因子 巨噬细胞集落刺激因子 |
| 英文关键词:Major depressive disorder Psychomotor retardation Cytokines Granulocyte colony-stimulating factor Macrophage colony-stimulating factor |
| 基金项目:上海市“科技创新行动计划”医学创新研究专项（项目名称：强化tDCS对难治性抑郁症疗效及基于皮层兴奋性和连接的预测研究，项目编号：21Y11905600）；上海市“科技创新行动计划”自然科学（项目名称：基于重置生物节律和miR-132调控探索睡眠剥夺快速抗抑郁机制，项目编号：21ZR1455100）；上海市精神卫生中心科研课题（项目名称：基于周细胞功能探讨PDGF-BB/PDGFRβ在抑郁症认知功能损害中的预测价值及机制探索，项目编号：2021-YJ02） |
|
| 摘要点击次数: |
| 全文下载次数: |
| 中文摘要: |
| 背景 抑郁障碍的发病机制与神经炎症密切相关，且异质性高，细化亚型有助于明确抑郁障碍的生物标志物。精神运动性迟滞严重影响抑郁障碍转归，但其机制尚不清楚。既往研究提示，粒细胞集落刺激因子（G-CSF）和巨噬细胞集落刺激因子（M-CSF）可能参与伴精神运动性迟滞的抑郁障碍发生过程，但目前研究不足。目的 分析抑郁障碍患者G-CSF和M-CSF水平与精神运动性迟滞的相关性，探索伴精神运动性迟滞抑郁障碍的潜在生物学特征。方法 纳入2018年4月―2019年4月在上海市精神卫生中心门诊就诊、符合《精神障碍诊断与统计手册（第5版）》（DSM-5）诊断标准的50例抑郁障碍患者为研究对象。采用汉密尔顿抑郁量表17项版（HAMD-17）评定抑郁障碍严重程度。根据HAMD-17迟滞因子评分对患者分组：该因子评分≥8分者为迟滞组（n=22），<8分者为无迟滞组（n=28）。同期招募与患者组年龄和性别相匹配的健康对照组共22例。使用Luminex液相悬浮芯片技术检测所有受试者血浆G-CSF和M-CSF水平。采用Spearman相关分析考查抑郁障碍患者HAMD-17迟滞因子评分与血浆G-CSF和M-CSF水平的关系。结果 抑郁障碍患者血浆G-CSF水平低于健康对照组［57.34（39.24，83.15）pg/mL vs.71.47（61.20，79.99）pg/mL，Z=-2.098，P<0.05］。迟滞组、无迟滞组、健康对照组血浆G-CSF水平差异有统计学意义［63.92（54.60，89.43）pg/mL vs. 47.80（33.41，74.66）pg/mL vs. 71.47（61.20，79.99）pg/mL，H=8.247，P=0.016］，三组血浆M-CSF水平差异有统计学意义［20.05（16.05，22.23）pg/mL vs. 13.05（11.43，17.50）pg/mL vs. 18.95（14.59，22.88）pg/mL，H=7.620，P=0.022］。事后两两比较显示，无迟滞组血浆G-CSF水平低于健康对照组（调整后P<0.05），迟滞组血浆M-CSF水平高于无迟滞组（调整后P<0.05）。抑郁障碍患者HAMD-17迟滞因子评分与血浆M-CSF水平呈正相关（r=0.348，P<0.05）。结论 抑郁障碍患者精神运动性迟滞可能与血浆M-CSF水平升高有关。 |
| 英文摘要: |
| Background The etiopathogenesis of major depressive disorder （MDD） is strongly associated with neuroinflammation. MDD is a highly heterogeneous psychiatric disorder， and the disease subtyping is an essential step for the identification of biological markers. The presence of psychomotor retardation seriously affects the prognosis of MDD， whereas the underlying mechanism is not yet completely clear. A potential involvement of granulocyte colony-stimulating factor （G-CSF） and macrophage colony-stimulating factor （M-CSF） in the pathogenesis of MDD with psychomotor retardation has been suggested in previous studies， but little detailed research has been completed.Objective To analyze the correlation of plasma G-CSF and M-CSF levels with psychomotor retardation in patients with MDD， and to explore the potential biological underpinnings of psychomotor retardation in MDD.Methods A total of 50 MDD patients who met the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders， fifth edition （DSM-5） and attended the outpatient clinics of Shanghai Mental Health Center from April 2018 to April 2019 were included. The severity of symptoms was assessed using the Hamilton Depression Scale-17 item （HAMD-17）. According to the retardation factor in HAMD-17， patients with a score of ≥8 were included in retardation group （n=22）， and those with a score below 8 were included in non-retardation group （n=28）. Another 22 age- and sex-matched healthy controls were concurrently recruited. Plasma G-CSF and M-CSF levels were measured in all subjects using Luminex liquid suspension chip technology. Spearman correlation analysis was adopted to verify the correlation of retardation factor score in HAMD-17 with plasma G-CSF and M-CSF levels in MDD patients.Results Plasma G-CSF levels were decreased in MDD patients compared with healthy controls ［57.34（39.24， 83.15）pg/mL vs. 71.47（61.20， 79.99）pg/mL， Z=-2.098， P<0.05］. A statistical difference was found in plasma G-CSF level ［63.92（54.60， 89.43）pg/mL vs. 47.80（33.41， 74.66）pg/mL vs. 71.47（61.20， 79.99）pg/mL， H=8.247， P=0.016］ and plasma M-CSF level ［20.05（16.05， 22.23）pg/mL vs. 13.05（11.43， 17.50）pg/mL vs. 18.95（14.59， 22.88）pg/mL， H=7.620， P=0.022］ among retardation group， non-retardation group and healthy control group. The post hoc pairwise comparisons using Bonferroni correction indicated that plasma G-CSF level was lower in non-retardation group compared with healthy control group （adjusted P<0.05）， and plasma M-CSF level was higher in retardation group compared with non-retardation group （adjusted P<0.05）. The retardation factor score in HAMD-17 was positively correlated with plasma M-CSF level in MDD patients （r=0.348， P<0.05）.Conclusion The prevalence of psychomotor retardation in MDD patients may be related to abnormally elevated plasma M-CSF level. ［Funded by Shanghai "Science and Technology Innovation Action Plan" Project in Medical Innovation Research Field （number， 21Y11905600）； Shanghai "Science and Technology Innovation Action Plan" Project in Natural Science Field （number， 21ZR1455100）； Shanghai Mental Health Center Scientific Research Project （number， 2021-YJ02）］ |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |