| 孙洪芳,陈玲,张静,王衍,刘洪双.卵巢癌患者元认知与生活质量的关系：恐惧疾病进展的中介作用[J].四川精神卫生杂志,2023,36(6):532-537.Sun Hongfang,Chen Ling,Zhang Jing,Wang Yan,Liu Hongshuang,Metacognition in relation to quality of life in patients with ovarian cancer： mediating role of fear of disease progression[J].SICHUAN MENTAL HEALTH,2023,36(6):532-537 |
| 卵巢癌患者元认知与生活质量的关系：恐惧疾病进展的中介作用 |
| Metacognition in relation to quality of life in patients with ovarian cancer： mediating role of fear of disease progression |
| 投稿时间：2023-02-25 |
| DOI：10.11886/scjsws20230225001 |
| 中文关键词: 卵巢癌 元认知 恐惧疾病进展 生活质量 中介作用 |
| 英文关键词:Ovarian cancer Metacognition Fear of disease progression Quality of life Mediating role |
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| 中文摘要: |
| 背景 生活质量是反映卵巢癌临床治疗效果的重要指标，患者不良的心理因素可能对生活质量产生负面影响，其中恐惧疾病进展在癌症幸存者中较常见，元认知对恐惧疾病进展有显著影响，但在卵巢癌患者中，三者关系尚需进一步研究。目的 探讨卵巢癌患者恐惧疾病进展、元认知和生活质量的关系，分析恐惧疾病进展在元认知与生活质量之间的作用，为改善卵巢癌患者生活质量提供参考。方法 连续选取2019年1月—2022年12月在河北省沧州市人民医院住院治疗的135例卵巢癌患者为研究对象。采用卵巢癌患者生命质量测定量表（FACT-O）评定患者生活质量，采用中文版恐惧疾病进展简化量表（FoP-Q-SF）评定患者恐惧疾病进展水平，采用元认知问卷（MCQ）评定患者元认知情况。采用Pearson相关分析考查各量表评分的相关性，采用Process 3.5宏程序对恐惧疾病进展在元认知与生活质量之间的中介效应进行分析，采用偏差校正的非参数百分位Bootstrap法对中介效应进行检验。结果 共122例（90.37%）卵巢癌患者完成有效问卷调查。患者FACT-O评分为（90.52±17.13）分，MCQ评分为（68.52±16.31）分，FoP-Q-SF评分为（37.72±8.91）分。Pearson相关分析显示，卵巢癌患者FoP-Q-SF评分与FACT-O评分呈负相关（r=-0.412，P<0.05），与MCQ评分呈正相关（r=0.241，P<0.05），MCQ评分与FACT-O评分呈负相关（r=-0.453，P<0.05）。中介效应分析显示，元认知对生活质量的总效应值为-0.298（95% CI：-0.402~-0.186），元认知对生活质量的直接效应为-0.219（95% CI：-0.504~-0.277），占总效应的73.49%，元认知通过恐惧疾病进展对生活质量的间接效应为-0.079（95% CI：-0.162~-0.037），占总效应的26.51%。结论 卵巢癌患者生活质量较低，恐惧疾病进展在元认知与生活质量之间起部分中介作用。 |
| 英文摘要: |
| Background Quality of life， as a major criterion for judging the clinical outcome of ovarian cancer patients， can be affected by adverse psychological symptoms of patients. Meanwhile， fear of disease progression， as a frequent psychological symptom among cancer survivors， is significantly influenced by metacognition， while there is a paucity of research into the specific correlation among the three in patients with ovarian cancer.Objective To explore the correlation among fear of disease progression， metacognition and quality of life in patients with ovarian cancer， and to test the role of fear of disease progression in the relationship between metacognition and quality of life， so as to provide references for improving the quality of life in patients with ovarian cancer.Methods A total of 135 patients with ovarian cancer hospitalized in Cangzhou People's Hospital of Hebei Province from January 2019 to December 2022 were selected. All subjects were requested to complete the Functional Assessment of Cancer Therapy-Ovarian Cancer （FACT-O）， Fear of Progression Questionnaire-Short Form （FoP-Q-SF） and Metacognition Questionnaire （MCQ） to assess their quality of life， fear of disease progression and metacognitive level. Pearson correlation analysis was adopted to examine the correlation among the above scales. Process v3.5 macro program was utilized to determine the mediating effect of fear of disease progression on the relationship between metacognition and quality of life， and nonparametric Bootstrap with bias-correction was used to test the mediating effect.Results A total of 122 patients （90.37%） with ovarian cancer completed the effective questionnaire survey. Patients scored （90.52±17.13） on FACT-O， （68.52±16.31） on MCQ， and （37.72±8.91） on FoP-Q-SF. Pearson correlation analysis denoted that FoP-Q-SF score was negatively correlated with FACT-O score （r=-0.412， P<0.05） and positively correlated with MCQ score （r=0.241， P<0.05）， and MCQ score was negatively correlated with FACT-O score （r=-0.453， P<0.05）. Analysis demonstrated that the total effect of metacognition on quality of life was -0.298 （95% CI： -0.402~-0.186）. The direct effect of metacognition on quality of life was -0.219 （95% CI： -0.504~-0.277）， accounting for 73.49% of the total effect， and the indirect effect of metacognition on quality of life via fear of disease progression was -0.079 （95% CI： -0.162~-0.037）， accounting for 26.51% of the total effect.Conclusion Quality of life is reduced in patients with ovarian cancer， and fear of disease progression plays a partial mediating role in the relationship between metacognition and quality of life. |
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