社区精神分裂症患者负性生活事件与失眠之间的关系:精神病性症状和抑郁的作用路径
Relationship between negative life events and insomnia in community schizophrenics: chain-mediated effects of psychotic symptoms and depressiondepression
投稿时间:2023-10-22  修订日期:2024-06-25
DOI:
中文关键词:  负性生活事件  失眠  精神病性症状  抑郁  精神分裂症
英文关键词:Negative Life events  Insomnia  Psychotic symptoms  Depression  Schizophrenia
基金项目:成都医学院研究生科研创新基金资助项目 ( 项目名称:社区精神分裂症患者负性生活事件、精神病症状与攻击行为的关系研究,项目编号:YCX2023-01-53)
作者单位地址
陈旭姝 成都医学院 四川省成都市金牛区蓉都大道601号
刘鑫 成都医学院 
何昌九* 成都市第四人民医院 成都市金牛区营门口路互利西一巷8号
熊朝新宇 四川大学华西公共卫生学院 
郭易 四川大学华西公共卫生学院 
魏泸懿 四川大学华西公共卫生学院 
刘元元 四川大学华西公共卫生学院 
张春熙 四川大学华西公共卫生学院 
刘祥 四川大学华西公共卫生学院 
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中文摘要:
      【摘要】背景 失眠是精神分裂症患者的常见症状。患者的负性生活事件、精神病性症状以及抑郁可能对失眠产生负面影响。但在社区精神分裂症患者中,四者关系尚需进一步探讨。 目的 探讨负性生活事件对社区精神分裂症患者失眠的影响以及精神病性症状与抑郁的作用路径,以期为社区精神分裂症患者失眠的干预提供参考。 方法 于2023年4月—6月,纳入四川省成都市48个社区卫生服务中心在管的精神分裂症患者1 105例。采用简版负性生活事件量表(SLEs)、阿斯森失眠量表(AIS)、精神病筛查问卷(PSQ)、患者健康问卷抑郁量表(PHQ-9)进行评定。采用Spearman相关分析考查各量表评分之间的相关性,采用偏最小二乘法和Bootstrap法检验中介效应。 结果 检出332例(30.05%)社区精神分裂症患者存在失眠。精神分裂症患者AIS评分与SLEs评分、PSQ评分、PHQ-9评分均呈正相关(r=0.165、0.322、0.554,P均<0.01)。神病性症状和抑郁分别在负性生活事件和失眠间起部分中介作用(间接效应值分别为0.102、0.372,分别占总效应的10.46%、38.15%)精神病性症状和抑郁在社区精神分裂症患者负面生活事件与失眠之间起链式中介作用(链式路径效应值为0.190,效应占比为19.49%)。 结论 社区精神分裂症患者的负性生活事件可以直接影响失眠,也可以通过精神病性症状和抑郁的独立或链式作用路径影响失眠。
英文摘要:
      Backgrounds Insomnia is a common symptom in patients with schizophrenia. Negative life events, psychotic symptoms, and depression in patients may have a negative impact on insomnia. However, the relationship between the four needs to be further explored in community-based schizophrenia patients. Objective To analyse the effects of negative life events on insomnia in community schizophrenia patients, and to explore the chain-mediated roles of psychotic symptoms and depression in the relationship between the two, so as to provide a reference basis for the intervention of insomnia in community schizophrenia patients. Methods From April to June 2023, 1 105 patients with schizophrenia under the management of 48 community health centres in Chengdu, Sichuan Province were included. The Short-Life Event Scale (SLEs), the Athens Insomnia Scale (AIS), the Psychosis Screening Questionnaire (PSQ), and Patients’ Health Questionnaire Depression Scale-9 item (PHQ-9) were used for assessment. Pearson's correlation analysis was used to examine the correlation of the scale scores, and partial least squares and Bootstrap methods were used to test for mediating effects. Results Insomnia was detected in 332 (30.05%) community schizophrenic patients. AIS scores were positively correlated with SLEs score, PSQ score, and PHQ-9 score in patients with schizophrenia (r=0.165、0.322、0.554, P<0.01). Psychotic symptoms and depression partially mediate between negative life events and insomnia. Indirect effect values were 0.102 and 0.372, with effect shares of 10.46% and 38.15%, respectively. Psychotic symptoms and depression as chain mediators between negative life events and insomnia in community schizophrenics (chained path effect value was 0.190, and accounted for 19.49 %). Conclusion The negative life events causes an impact on insomnia both directly and indirectly through the chain mediating effect of Psychotic symptoms and depression.
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